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Type: Artigo
Title: Liposomal lidocaine gel for topical use at the oral mucosa: characterization, in vitro assays and in vivo anesthetic efficacy in humans.
Author: Franz-Montan, Michelle
Baroni, Daniela
Brunetto, Giovana
Sobral, Viviane Roberta Vieira
da Silva, Camila Morais Gonçalves
Venâncio, Paulo
Zago, Patricia Wiziack
Cereda, Cintia Maria Saia
Volpato, Maria Cristina
de Araújo, Daniele Ribeiro
de Paula, Eneida
Groppo, Francisco Carlos
Abstract: To characterize liposomal-lidocaine formulations for topical use on oral mucosa and to compare their in vitro permeation and in vivo anesthetic efficacy with commercially available lidocaine formulations. Large unilamellar liposomes (400 nm) containing lidocaine were prepared using phosphatidylcholine, cholesterol, and α-tocoferol (4:3:0.07, w:w:w) and were characterized in terms of membrane/water partition coefficient, encapsulation efficiency, size, polydispersity, zeta potential, and in vitro release. In vitro permeation across pig palatal mucosa and in vivo topical anestheticefficacy on the palatal mucosa in healthy volunteers (double-blinded cross-over, placebo controlled study) were performed. The following formulations were tested: liposome-encapsulated 5% lidocaine (Liposome-Lido5); liposome-encapsulated 2.5% lidocaine (Liposome-Lido2.5); 5% lidocaine ointment (Xylocaina®), and eutectic mixture of lidocaine and prilocaine 2.5% (EMLA®). The Liposome-Lido5 and EMLA showed the best in vitro permeation parameters (flux and permeability coefficient) in comparison with Xylocaina and placebo groups, as well as the best in vivo topical anesthetic efficacy. We successfully developed and characterized a liposome encapsulated 5% lidocaine gel. It could be considered an option to other topical anesthetic agents for oral mucosa
Subject: Mucosa bucal
Country: Estados Unidos
Editor: Taylor & Francis
Citation: Journal Of Liposome Research. v. 25, n. 1, p. 11-9, 2015-Mar.
Rights: fechado
Identifier DOI: 10.3109/08982104.2014.911315
Date Issue: 2015
Appears in Collections:IB - Artigos e Outros Documentos
FOP - Artigos e Outros Documentos

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