Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/201969
Type: Artigo de periódico
Title: Lymphocyte Activation In Silica-exposed Workers.
Author: Rocha-Parise, Michelle
Santos, Leonilda M B
Damoiseaux, Jan G M C
Bagatin, Ericson
Lido, Alessandro V
Torello, Cristiane Okuda
Cohen Tervaert, Jan W
Queiroz, Mary L S
Abstract: Exposure to silica dust has been examined as a possible risk factor for autoimmune diseases, including systemic sclerosis, rheumatoid arthritis, systemic lupus erythematosus and ANCA-associated vasculitis. However, the underlying cellular and molecular mechanisms resulting in the increased prevalence of autoimmunity remain elusive. To clarify these mechanisms, we studied various markers of immune activation in individuals occupationally exposed to silica dust, i.e., serum levels of soluble IL-2 receptor (sIL-2R), levels of IL-2, other pro- and anti-inflammatory cytokines and lymphoproliferation. Our results demonstrate that silica-exposed individuals present important alterations in their immune response when compared to controls, as shown by increased serum sIL-2R levels, decreased production of IL-2 and increased levels of the pro-inflammatory (IFN-γ, IL-1α, TNF-α, IL-6) as well as anti-inflammatory (IL-10 and TGF-β) cytokines. Furthermore, silica-exposed individuals presented enhanced lymphoproliferative responses. Our findings provide evidence that the maintenance of immune homeostasis may be disturbed in silica-exposed individuals, possibly resulting in autoimmune disorders.
Subject: Aged
Brazil
Cell Proliferation
Environmental Pollutants
Female
Humans
Interleukin-2
Leukocytes, Mononuclear
Lymphocyte Activation
Male
Middle Aged
Occupational Exposure
Receptors, Interleukin-2
Silicon Dioxide
Autoimmunity
Cytokines
Interleukin-2
Lymphocytes
Silica
Soluble Il-2 Receptor Alpha
Rights: fechado
Identifier DOI: 10.1016/j.ijheh.2013.11.002
Address: http://www.ncbi.nlm.nih.gov/pubmed/24332681
Date Issue: -1-Uns- -1
Appears in Collections:Unicamp - Artigos e Outros Documentos

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