Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/201936
Type: Artigo de periódico
Title: A New Platinum Complex With Tryptophan: Synthesis, Structural Characterization, Dft Studies And Biological Assays In Vitro Over Human Tumorigenic Cells.
Author: Carvalho, Marcos A
Shishido, Silvia M
Souza, Bárbara C
de Paiva, Raphael E F
Gomes, Alexandre F
Gozzo, Fábio C
Formiga, André L B
Corbi, Pedro P
Abstract: A new platinum(II) complex with the amino acid L-tryptophan (trp), named Pt-trp, was synthesized and characterized. Elemental, thermogravimetric and ESI-QTOF mass spectrometric analyses led to the composition [Pt(C11H11N2O2)2]⋅6H2O. Infrared spectroscopic data indicate the coordination of trp to Pt(II) through the oxygen of the carboxylate group and also through the nitrogen atom of the amino group. The (13)C CP/MAS NMR spectroscopic data confirm coordination through the oxygen atom of the carboxylate group, while the (15)N CP/MAS NMR data confirm coordination of the nitrogen of the NH2 group to the metal. Density functional theory (DFT) studies were applied to evaluate the cis and trans coordination modes of trp to platinum(II). The trans isomer was shown to be energetically more stable than the cis one. The Pt-trp complex was evaluated as a cytotoxic agent against SK-Mel 103 (human melanoma) and Panc-1 (human pancreatic carcinoma) cell lines. The complex was shown to be cytotoxic over the considered cells.
Subject: 3t3 Cells
Animals
Biological Assay
Carbon-13 Magnetic Resonance Spectroscopy
Cell Death
Cell Line, Tumor
Cell Survival
Humans
Mass Spectrometry
Mice
Models, Molecular
Molecular Conformation
Platinum
Quantum Theory
Spectrophotometry, Infrared
Thermogravimetry
Tryptophan
Vibration
Antitumoral Assays
Esi-qtof-ms
L-tryptophan
Molecular Modeling
Platinum(ii)
Rights: fechado
Identifier DOI: 10.1016/j.saa.2013.11.044
Address: http://www.ncbi.nlm.nih.gov/pubmed/24316534
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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