Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/201931
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampCervigne, Nilva de Karlapt_BR
dc.contributor.authorunicampOliveira, Carine Ervolino dept_BR
dc.contributor.authorunicampFonseca, Felipe Paivapt_BR
dc.contributor.authorunicampLopes, Márcio Ajudartept_BR
dc.contributor.authorunicampSantos-Silva, Alan Rogerpt_BR
dc.contributor.authorunicampGraner, Edgardpt_BR
dc.contributor.authorunicampDella Coletta, Ricardopt_BR
dc.typeArtigopt_BR
dc.titleAgrin and perlecan mediate tumorigenic processes in oral squamous cell carcinomapt_BR
dc.contributor.authorKawahara, Rebecapt_BR
dc.contributor.authorGranato, Daniela C.pt_BR
dc.contributor.authorCarnielli, Carolina M.pt_BR
dc.contributor.authorCervigne, Nilva K.pt_BR
dc.contributor.authorOliveira, Carine E.pt_BR
dc.contributor.authorMartinez, César A. R.pt_BR
dc.contributor.authorYokoo, Samipt_BR
dc.contributor.authorFonseca, Felipe P.pt_BR
dc.contributor.authorLopes, Marciopt_BR
dc.contributor.authorSantos-Silva, Alan R.pt_BR
dc.contributor.authorGraner, Edgardpt_BR
dc.contributor.authorColetta, Ricardo D.pt_BR
dc.contributor.authorPaes Leme, Adriana Francopt_BR
dc.subjectCarcinoma de células escamosaspt_BR
dc.subjectBoca - Doençaspt_BR
dc.subject.otherlanguageCarcinoma, squamous cellpt_BR
dc.subject.otherlanguageMouth - Diseasespt_BR
dc.description.abstractOral squamous cell carcinoma is the most common type of cancer in the oral cavity, representing more than 90% of all oral cancers. The characterization of altered molecules in oral cancer is essential to understand molecular mechanisms underlying tumor progression as well as to contribute to cancer biomarker and therapeutic target discovery. Proteoglycans are key molecular effectors of cell surface and pericellular microenvironments, performing multiple functions in cancer. Two of the major basement membrane proteoglycans, agrin and perlecan, were investigated in this study regarding their role in oral cancer. Using real time quantitative PCR (qRT-PCR), we showed that agrin and perlecan are highly expressed in oral squamous cell carcinoma. Interestingly, cell lines originated from distinct sites showed different expression of agrin and perlecan. Enzymatically targeting chondroitin sulfate modification by chondroitinase, oral squamouscarcinoma cell line had a reduced ability to adhere to extracellular matrix proteins and increased sensibility to cisplatin. Additionally, knockdown of agrin and perlecan promoted a decrease on cell migration and adhesion, and on resistance of cells to cisplatin. Our study showed, for the first time, a negative regulation on oral cancer-associated events by either targeting chondroitin sulfate content or agrin and perlecan levelspt
dc.relation.ispartofPLoS onept_BR
dc.relation.ispartofabbreviationPLoS onept_BR
dc.publisher.citySan Francisco, CApt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherPublic Library of Sciencept_BR
dc.date.issued2014pt_BR
dc.identifier.citationPlos One. v. 9, n. 12, p. e115004, 2014.pt_BR
dc.language.isoengpt_BR
dc.description.volume9pt_BR
dc.description.issuenumber12pt_BR
dc.rightsabertopt_BR
dc.sourcePubMedpt_BR
dc.identifier.eissn1932-6203pt_BR
dc.identifier.doi10.1371/journal.pone.0115004pt_BR
dc.identifier.urlhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115004pt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorship1FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOpt_BR
dc.description.sponsorship1CNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOpt_BR
dc.description.sponsordocumentnumber2009/54067-3; 2010/19278-0; 2011/22421-2pt_BR
dc.description.sponsordocumentnumber470549/2011-4; 301702/2011-0; 470268/2013-1pt_BR
dc.date.available2015-11-27T13:43:54Z-
dc.date.accessioned2015-11-27T13:43:54Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:43:54Z (GMT). No. of bitstreams: 1 pmed_25506919.pdf: 1147398 bytes, checksum: 54877d2c9792dcf210f7a1b1273240f1 (MD5) Previous issue date: 2014 Bitstreams deleted on 2020-05-14T20:38:53Z: pmed_25506919.pdf,. Added 1 bitstream(s) on 2020-05-14T20:43:13Z : No. of bitstreams: 1 25506919.pdf: 478264 bytes, checksum: c8282ce0bd7af0ecbf311c35eb915b13 (MD5) Bitstreams deleted on 2020-06-04T12:48:06Z: 25506919.pdf,. Added 1 bitstream(s) on 2020-06-04T12:53:17Z : No. of bitstreams: 1 25506919.pdf: 1633471 bytes, checksum: ae5e6c882780a6e46c381405f4073327 (MD5)en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201931-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Diagnóstico Oralpt_BR
dc.contributor.departmentDepartamento de Diagnóstico Oralpt_BR
dc.contributor.departmentDepartamento de Diagnóstico Oralpt_BR
dc.contributor.departmentDepartamento de Diagnóstico Oralpt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.identifier.source25506919-
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0001-6677-0065pt_BR
dc.creator.orcid0000-0003-2040-6617pt_BR
dc.creator.orcid0000-0002-4737-7935pt_BR
dc.creator.orcid0000-0001-5285-3046pt_BR
dc.type.formArtigopt_BR
dc.identifier.articleide115004pt_BR
dc.identifier.articleide115004-
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