Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/201931
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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt
dc.typeArtigo de periódicopt
dc.titleAgrin And Perlecan Mediate Tumorigenic Processes In Oral Squamous Cell Carcinoma.pt
dc.contributor.authorKawahara, Rebecapt
dc.contributor.authorGranato, Daniela Cpt
dc.contributor.authorCarnielli, Carolina Mpt
dc.contributor.authorCervigne, Nilva Kpt
dc.contributor.authorOliveria, Carine Ept
dc.contributor.authorMartinez, César A Rpt
dc.contributor.authorYokoo, Samipt
dc.contributor.authorFonseca, Felipe Ppt
dc.contributor.authorLopes, Marciopt
dc.contributor.authorSantos-Silva, Alan Rpt
dc.contributor.authorGraner, Edgardpt
dc.contributor.authorColetta, Ricardo Dpt
dc.contributor.authorPaes Leme, Adriana Francopt
unicamp.authorNilva K Cervigne, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, UNICAMP, Piracicaba, Brazil.pt
unicamp.authorCarine E Oliveria, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, UNICAMP, Piracicaba, Brazil.pt
unicamp.authorFelipe P Fonseca, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, UNICAMP, Piracicaba, Brazil.pt
unicamp.authorMarcio Lopes, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, UNICAMP, Piracicaba, Brazil.pt
unicamp.authorAlan R Santos-Silva, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, UNICAMP, Piracicaba, Brazil.pt
unicamp.authorEdgard Graner, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, UNICAMP, Piracicaba, Brazil.pt
unicamp.authorRicardo D Coletta, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, UNICAMP, Piracicaba, Brazil.pt
unicamp.author.externalRebeca Kawahara, Laboratório de Espectrometria de Massas, Laboratório Nacional de Biociências, LNBio, CNPEM, Campinas, Brazil.pt
unicamp.author.externalDaniela C Granato, Laboratório de Espectrometria de Massas, Laboratório Nacional de Biociências, LNBio, CNPEM, Campinas, Brazil.pt
unicamp.author.externalCarolina M Carnielli, Laboratório de Espectrometria de Massas, Laboratório Nacional de Biociências, LNBio, CNPEM, Campinas, Brazil.pt
unicamp.author.externalCésar A R Martinez, Laboratório de Espectrometria de Massas, Laboratório Nacional de Biociências, LNBio, CNPEM, Campinas, Brazil.pt
unicamp.author.externalSami Yokoo, Laboratório de Espectrometria de Massas, Laboratório Nacional de Biociências, LNBio, CNPEM, Campinas, Brazil.pt
unicamp.author.externalAdriana Franco Paes Leme, Laboratório de Espectrometria de Massas, Laboratório Nacional de Biociências, LNBio, CNPEM, Campinas, Brazil.pt
dc.description.abstractOral squamous cell carcinoma is the most common type of cancer in the oral cavity, representing more than 90% of all oral cancers. The characterization of altered molecules in oral cancer is essential to understand molecular mechanisms underlying tumor progression as well as to contribute to cancer biomarker and therapeutic target discovery. Proteoglycans are key molecular effectors of cell surface and pericellular microenvironments, performing multiple functions in cancer. Two of the major basement membrane proteoglycans, agrin and perlecan, were investigated in this study regarding their role in oral cancer. Using real time quantitative PCR (qRT-PCR), we showed that agrin and perlecan are highly expressed in oral squamous cell carcinoma. Interestingly, cell lines originated from distinct sites showed different expression of agrin and perlecan. Enzymatically targeting chondroitin sulfate modification by chondroitinase, oral squamous carcinoma cell line had a reduced ability to adhere to extracellular matrix proteins and increased sensibility to cisplatin. Additionally, knockdown of agrin and perlecan promoted a decrease on cell migration and adhesion, and on resistance of cells to cisplatin. Our study showed, for the first time, a negative regulation on oral cancer-associated events by either targeting chondroitin sulfate content or agrin and perlecan levels.en
dc.relation.ispartofPlos Oneen
dc.relation.ispartofabbreviationPLoS ONEpt
dc.date.issued2014pt
dc.identifier.citationPlos One. v. 9, n. 12, p. e115004, 2014.pt
dc.language.isoengpt
dc.description.volume9pt
dc.description.initialpagee115004pt
dc.rightsabertopt
dc.rights.holderpt
dc.sourcePubMedpt
dc.identifier.issn1932-6203pt
dc.identifier.doi10.1371/journal.pone.0115004pt
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/25506919en
dc.date.available2015-11-27T13:43:54Z-
dc.date.accessioned2015-11-27T13:43:54Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:43:54Z (GMT). No. of bitstreams: 1 pmed_25506919.pdf: 1147398 bytes, checksum: 54877d2c9792dcf210f7a1b1273240f1 (MD5) Previous issue date: 2014en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201931-
dc.identifier.idPubmed25506919pt
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