Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/201826
Type: Artigo de periódico
Title: Deregulation Of Adipokines Related To Target Organ Damage On Resistant Hypertension.
Author: Sabbatini, A R
Faria, A P
Barbaro, N R
Gordo, W M
Modolo, R G P
Pinho, C
Fontana, V
Moreno, H
Abstract: Resistant hypertension (RHTN) includes patients with controlled blood pressure (BP) (CRHTN) and uncontrolled BP (UCRHTN). In fact, RHTN patients are more likely to have target organ damage (TOD), and resistin, leptin and adiponectin may affect BP control in these subjects. We assessed the relationship between adipokines levels and arterial stiffness, left ventricular hypertrophy (LVH) and microalbuminuria (MA). This cross-sectional study included CRHTN (n=51) and UCRHTN (n=38) patients for evaluating body mass index, ambulatory blood pressure monitoring, plasma adiponectin, leptin and resistin concentrations, pulse wave velocity (PWV), MA and echocardiography. Leptin and resistin levels were higher in UCRHTN, whereas adiponectin levels were lower in this same subgroup. Similarly, arterial stiffness, LVH and MA were higher in UCRHTN subgroup. Adiponectin levels negatively correlated with PWV (r=-0.42, P<0.01), and MA (r=-0.48, P<0.01) only in UCRHTN. Leptin was positively correlated with PWV (r=0.37, P=0.02) in UCRHTN subgroup, whereas resistin was not correlated with TOD in both subgroups. Adiponectin is associated with arterial stiffness and renal injury in UCRHTN patients, whereas leptin is associated with arterial stiffness in the same subgroup. Taken together, our results showed that those adipokines may contribute to vascular and renal damage in UCRHTN patients.
Subject: Adipokines
Adiponectin
Aged
Albuminuria
Antihypertensive Agents
Biological Markers
Blood Chemical Analysis
Blood Pressure Monitoring, Ambulatory
Body Mass Index
Brazil
Cross-sectional Studies
Disease Progression
Drug Resistance
Echocardiography, Doppler
Female
Humans
Hypertension
Hypertrophy, Left Ventricular
Leptin
Linear Models
Male
Middle Aged
Multivariate Analysis
Prognosis
Pulse Wave Analysis
Resistin
Statistics, Nonparametric
Vascular Resistance
Vascular Stiffness
Rights: fechado
Identifier DOI: 10.1038/jhh.2013.118
Address: http://www.ncbi.nlm.nih.gov/pubmed/24284384
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.