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Type: Artigo de periódico
Title: Antioxidant And Anti-diabetic Potential Of Passiflora Alata Curtis Aqueous Leaves Extract In Type 1 Diabetes Mellitus (nod-mice).
Author: Colomeu, T C
Figueiredo, D
Cazarin, C B B
Schumacher, N S G
Maróstica, M R
Meletti, L M M
Zollner, R L
Abstract: Leaves of Passiflora alata Curtis were characterized for their antioxidant capacity. Antioxidant analyses of DPPH, FRAP, ABTS, ORAC and phenolic compounds were made in three different extracts: aqueous, methanol/acetone and ethanol. Aqueous extract was found to be the best solvent for recovery of phenolic compounds and antioxidant activity, when compared with methanol/acetone and ethanol. To study the anti-inflammatory properties of this extract in experimental type 1 diabetes, NOD mice were divided into two groups: the P. alata group, treated with aqueous extract of P. alata Curtis, and a non-treated control group, followed by diabetes expression analysis. The consumption of aqueous extract and water ad libitum lasted 28 weeks. The treated-group presented a decrease in diabetes incidence, a low quantity of infiltrative cells in pancreatic islets and increased glutathione in the kidney and liver (p<0.05), when compared with the diabetic and non-diabetic control-groups. In conclusion, our results suggest that the consumption of aqueous extract of P. alata may be considered a good source of natural antioxidants and compounds found in its composition can act as anti-inflammatory agents, helping in the control of diabetes.
Subject: Animals
Cell Movement
Diabetes Mellitus, Type 1
Disease Models, Animal
Hypoglycemic Agents
Insulin-secreting Cells
Mice, Inbred Nod
Oxidative Stress
Plant Extracts
Plant Leaves
Antioxidant Capacity
Glutathione (gsh)
Non-obese Diabetic Mice
Passiflora Alata Curtis
Type 1 Diabetes Mellitus
Citation: International Immunopharmacology. v. 18, n. 1, p. 106-15, 2014-Jan.
Rights: fechado
Identifier DOI: 10.1016/j.intimp.2013.11.005
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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