Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/201735
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampFonseca, Felipe Paivapt_BR
dc.contributor.authorunicampDella Coletta, Ricardopt_BR
dc.contributor.authorunicampAzevedo, Marina Barbosapt_BR
dc.contributor.authorunicampVargas, Pablo Agustinpt_BR
dc.contributor.authorunicampAlmeida, Oslei Paes dept_BR
dc.contributor.authorunicampLopes, Márcio Ajudartept_BR
dc.contributor.authorunicampSantos-Silva, Alan Rogerpt_BR
dc.typeArtigopt_BR
dc.titleStromal myofibroblasts in squamous cell carcinoma of the tongue in young patients - a multicenter collaborative studypt_BR
dc.contributor.authorFonseca, Felipe Paivapt_BR
dc.contributor.authorColetta, Ricardo Dellapt_BR
dc.contributor.authorAzevedo, Marina Barbosapt_BR
dc.contributor.authorPrado Ribeiro, Ana Carolinapt_BR
dc.contributor.authorPires Soubhia, Ana Mariapt_BR
dc.contributor.authorMiyahara, Glauco Issamupt_BR
dc.contributor.authorCarlos, Romanpt_BR
dc.contributor.authorFarthing, Paulapt_BR
dc.contributor.authorHunter, Keith D.pt_BR
dc.contributor.authorSpeight, Paul M.pt_BR
dc.contributor.authorVargas, Pablo Agustinpt_BR
dc.contributor.authorAlmeida, Oslei Paespt_BR
dc.contributor.authorLopes, Marcio Ajudartept_BR
dc.contributor.authorSantos-Silva, Alan Rogerpt_BR
unicamp.authorFelipe Paiva Fonseca, Department of Oral Diagnosis, University of Campinas (UNICAMP), Piracicaba Dental School, Piracicaba, Brazil.pt_BR
unicamp.authorRicardo Della Coletta, Department of Oral Diagnosis, University of Campinas (UNICAMP), Piracicaba Dental School, Piracicaba, Brazil.pt_BR
unicamp.authorMarina Barbosa Azevedo, Department of Oral Diagnosis, University of Campinas (UNICAMP), Piracicaba Dental School, Piracicaba, Brazil.pt_BR
unicamp.authorPablo Agustin Vargas, Department of Oral Diagnosis, University of Campinas (UNICAMP), Piracicaba Dental School, Piracicaba, Brazil.pt_BR
unicamp.authorOslei Paes Almeida, Department of Oral Diagnosis, University of Campinas (UNICAMP), Piracicaba Dental School, Piracicaba, Brazil.pt_BR
unicamp.authorMarcio Ajudarte Lopes, Department of Oral Diagnosis, University of Campinas (UNICAMP), Piracicaba Dental School, Piracicaba, Brazil.pt_BR
unicamp.authorAlan Roger Santos-Silva, Department of Oral Diagnosis, University of Campinas (UNICAMP), Piracicaba Dental School, Piracicaba, Brazil. Electronic address: Alanroger@fop.unicamp.br.pt_BR
unicamp.author.externalAna Carolina Prado Ribeiro, Service of Dental Oncology, Instituto do Cancer do Estado de São Paulo (ICESP), Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil.pt
unicamp.author.externalAna Maria Pires Soubhia, Department of Pathology and Clinical Propedeutic, Univ Estadual Paulista (UNESP), Araçatuba Dental School, Araçatuba, Brazil.pt
unicamp.author.externalGlauco Issamu Miyahara, Department of Pathology and Clinical Propedeutic, Univ Estadual Paulista (UNESP), Araçatuba Dental School, Araçatuba, Brazil.pt
unicamp.author.externalRoman Carlos, Centro Clinico de Cabeza y Cuello, Guatemala City, Guatemala.pt
unicamp.author.externalPaula Farthing, Academic Unit of Oral and Maxillofacial Pathology, The University of Sheffield, School of Clinical Dentistry, Sheffield, UK.pt
unicamp.author.externalKeith D Hunter, Academic Unit of Oral and Maxillofacial Pathology, The University of Sheffield, School of Clinical Dentistry, Sheffield, UK.pt
unicamp.author.externalPaul M Speight, Academic Unit of Oral and Maxillofacial Pathology, The University of Sheffield, School of Clinical Dentistry, Sheffield, UK.pt
dc.subjectCarcinoma de células escamosas, Línguapt_BR
dc.subject.otherlanguageCarcinoma, squamous cellpt_BR
dc.subject.otherlanguageTonguept_BR
dc.description.abstractThe purpose of this study was to evaluate the presence of myofibroblasts, frequently associated with a more aggressive neoplastic behavior, in oral tongue squamous cell carcinoma (TSCC) of young patients and to compare with the distribution observed in older patients. Tumor samples from 29 patients younger than 40 years old affected by TSCC were retrieved and investigated for the presence of stromal myofibroblasts by immunohistochemical reactions against α smooth muscle actin, and the results obtained were compared to TSCC cases affecting older patients. No positive reaction could be found in the stromal areas devoid of neoplastic tissue, whereas myofibroblasts were present in 58.6% of the lesions in young patients and in 75.9% of the older ones. No significant difference was found when comparing the invasive front and the overall stroma of both groups, and no correlation could be obtained with stromal α smooth muscle actin expression, higher tumor grades or clinical stage (P > .05). There was no significant difference between the presence of stromal myofibroblasts of TSCC affecting young and old individuals.en
dc.description.abstractThe purpose of this study was to evaluate the presence of myofibroblasts, frequently associated with a more aggressive neoplastic behavior, in oral tongue squamous cell carcinoma (TSCC) of young patients and to compare with the distribution observed in older patients. Tumor samples from 29 patients younger than 40 years old affected by TSCC were retrieved and investigated for the presence of stromal myofibroblasts by immunohistochemical reactions against α smooth muscle actin, and the results obtained were compared to TSCC cases affecting older patients. No positive reaction could be found in the stromal areas devoid of neoplastic tissue, whereas myofibroblasts were present in 58.6% of the lesions in young patients and in 75.9% of the older ones. No significant difference was found when comparing the invasive front and the overall stroma of both groups, and no correlation could be obtained with stromal α smooth muscle actin expression, higher tumor grades or clinical stage (P > .05). There was no significant difference between the presence of stromal myofibroblasts of TSCC affecting young and old individualspt
dc.relation.ispartofOral surgery, oral medicine, oral pathology and oral radiologypt_BR
dc.relation.ispartofabbreviationOral surg oral med, oral pathol, oral radiolpt_BR
dc.publisher.cityAmsterdampt_BR
dc.publisher.countryHolandapt_BR
dc.publisherElsevierpt_BR
dc.date.issued2014pt_BR
dc.date.monthofcirculationOct.pt_BR
dc.identifier.citationOral Surgery, Oral Medicine, Oral Pathology And Oral Radiology. v. 118, n. 4, p. 483-9, 2014-Oct.pt_BR
dc.language.isoengpt_BR
dc.description.volume118pt_BR
dc.description.issuenumber4pt_BR
dc.description.firstpage483pt_BR
dc.description.lastpage489pt_BR
dc.rightsfechadopt_BR
dc.rights.holderCopyright © 2014 Elsevier Inc. All rights reserved.pt_BR
dc.sourcePUBMEDpt_br
dc.identifier.issn2212-4403pt_BR
dc.identifier.eissn2212-4411pt_BR
dc.identifier.doi10.1016/j.oooo.2014.07.012pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S2212440314006567pt_BR
dc.date.available2015-11-27T13:43:24Z-
dc.date.accessioned2015-11-27T13:43:24Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:43:24Z (GMT). No. of bitstreams: 1 pmed_25240996.pdf: 2400879 bytes, checksum: 414c553b749b0bdf27a7817192a0a922 (MD5) Previous issue date: 2014 Bitstreams deleted on 2020-05-14T20:38:52Z: pmed_25240996.pdf,. Added 1 bitstream(s) on 2020-05-14T20:43:12Z : No. of bitstreams: 1 25240996.pdf: 475412 bytes, checksum: 281906c64c944c54fd0b972fc17132fb (MD5) Bitstreams deleted on 2020-06-04T12:48:05Z: 25240996.pdf,. Added 1 bitstream(s) on 2020-06-04T12:53:16Z : No. of bitstreams: 1 25240996.pdf: 2885169 bytes, checksum: 9efd1785b63dfca17e3422a565d4e446 (MD5)en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201735-
dc.identifier.idPubmed25240996pt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Diagnóstico Oralpt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Diagnóstico Oralpt_BR
dc.contributor.departmentDepartamento de Diagnóstico Oralpt_BR
dc.contributor.departmentDepartamento de Diagnóstico Oralpt_BR
dc.contributor.departmentDepartamento de Diagnóstico Oralpt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.identifier.source25240996-
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0003-1840-4911pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0003-1840-4911pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0001-6677-0065pt_BR
dc.creator.orcid0000-0003-2040-6617pt_BR
dc.type.formArtigo-
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