Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/201731
Type: Artigo de periódico
Title: Understanding Red Blood Cell Parameters In The Context Of The Frailty Phenotype: Interpretations Of The Fibra (frailty In Brazilian Seniors) Study.
Author: Silva, João Carlos
Moraes, Zélia Vieira de
Silva, Conceição
Mazon, Silvia de Barros
Guariento, Maria Elena
Neri, Anita Liberalesso
Fattori, André
Abstract: Frailty and anemia in the elderly appear to share a common pathophysiology associated with chronic inflammatory processes. This study uses an analytical, cross-sectional, population-based methodology to investigate the probable relationships between frailty, red blood cell parameters and inflammatory markers in 255 community-dwelling elders aged 65 years or older. The frailty phenotype was assessed by non-intentional weight loss, fatigue, low grip strength, low energy expenditure and reduced gait speed. Blood sample analyses were performed to determine hemoglobin level, hematocrit and reticulocyte count, as well as the inflammatory variables IL-6, IL-1ra and hsCRP. In the first multivariate analysis (model I), considering only the erythroid parameters, Hb concentration was a significant variable for both general frailty status and weight loss: a 1.0g/dL drop in serum Hb concentration represented a 2.02-fold increase (CI 1.12-3.63) in an individual's chance of being frail. In the second analysis (model II), which also included inflammatory cytokine levels, hsCRP was independently selected as a significant variable. Each additional year of age represented a 1.21-fold increase in the chance of being frail, and each 1-unit increase in serum hsCRP represented a 3.64-fold increase in the chance of having the frailty phenotype. In model II reticulocyte counts were associated with weight loss and reduced metabolic expenditure criteria. Our findings suggest that reduced Hb concentration, reduced RetAbs count and elevated serum hsCRP levels should be considered components of frailty, which in turn is correlated with sarcopenia, as evidenced by weight loss.
Subject: Aged
Anemia
Brazil
Cross-sectional Studies
Erythrocyte Count
Fatigue
Female
Frail Elderly
Gait
Geriatric Assessment
Hand Strength
Hematocrit
Hemoglobins
Humans
Interleukin-6
Male
Multivariate Analysis
Phenotype
Prevalence
Residence Characteristics
Sarcopenia
Sex Distribution
Weight Loss
(red Blood Cell Distribution Width) Rdw
Anemia
Elderly
Frailty
Reticulocytes
Rights: fechado
Identifier DOI: 10.1016/j.archger.2014.07.014
Address: http://www.ncbi.nlm.nih.gov/pubmed/25236441
Date Issue: -1-Uns- -1
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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