Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/201705
Type: Artigo de periódico
Title: Gastroprotective Effects (in Rodents) Of A Flavonoid Rich Fraction Obtained From Syngonanthus Macrolepsis.
Author: Batista, Leônia Maria
de Almeida, Ana Beatriz Albino
Lima, Gedson Rodrigues de Morais
Falcão, Heloina de Sousa
Magri, Luciana de Pietro
Luiz-Ferreira, Anderson
dos Santos, Lourdes Campaner
Hiruma-Lima, Clélia Akiko
Vilegas, Wagner
Brito, Alba Regina Monteiro Souza
Abstract: Syngonanthus macrolepis, popularly known in Brazil as 'sempre-vivas', is a plant from the family Eriocaulaceae, it is found in the states of Minas Gerais and Bahia. The species contains a variety of constituents, including flavonoids with gastroprotective effect. In this work, a flavonoid-rich fraction (Sm-FRF) obtained from scapes of S. macrolepis was investigated for preventing gastric ulceration in mice and rats. The activity was evaluated in models of induced gastric ulcer (absolute ethanol, stress, non-steroidal anti-inflammatory drugs and pylorus ligation). The cytoprotective mechanisms of the Sm-FRF in relation to sulfhydryl (SH) groups, nitric oxide (NO) and antioxidant enzymes were also evaluated. The Sm-FRF (100 mg/kg, p.o.) significantly reduced gastric injury in all models, and did not alter gastric juice parameters after pylorus ligation. The results indicate significant gastroprotective activity for the Sm-FRF, which probably involves the participation of both SH groups and the antioxidant system. Both are integral parts of the gastrointestinal mucosa's cytoprotective mechanisms against aggressive factors.
Subject: Animals
Anti-ulcer Agents
Antioxidants
Disease Models, Animal
Eriocaulaceae
Flavonoids
Gastric Juice
Gastric Mucosa
Ligation
Mice
Mice, Inbred Strains
Nitric Oxide
Phytotherapy
Plant Extracts
Rats
Rats, Wistar
Stomach Ulcer
Sulfhydryl Compounds
Eriocaulaceae
Syngonanthus Macrolepsis
Flavonoid
Gastroprotective Activity
Medicinal Plants
Rights: fechado
Identifier DOI: 10.1111/jphp.12175
Address: http://www.ncbi.nlm.nih.gov/pubmed/24237033
Date Issue: 2014
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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