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Type: Artigo de periódico
Title: Gastroprotective Effects (in Rodents) Of A Flavonoid Rich Fraction Obtained From Syngonanthus Macrolepsis.
Author: Batista, Leônia Maria
de Almeida, Ana Beatriz Albino
Lima, Gedson Rodrigues de Morais
Falcão, Heloina de Sousa
Magri, Luciana de Pietro
Luiz-Ferreira, Anderson
dos Santos, Lourdes Campaner
Hiruma-Lima, Clélia Akiko
Vilegas, Wagner
Brito, Alba Regina Monteiro Souza
Abstract: Syngonanthus macrolepis, popularly known in Brazil as 'sempre-vivas', is a plant from the family Eriocaulaceae, it is found in the states of Minas Gerais and Bahia. The species contains a variety of constituents, including flavonoids with gastroprotective effect. In this work, a flavonoid-rich fraction (Sm-FRF) obtained from scapes of S. macrolepis was investigated for preventing gastric ulceration in mice and rats. The activity was evaluated in models of induced gastric ulcer (absolute ethanol, stress, non-steroidal anti-inflammatory drugs and pylorus ligation). The cytoprotective mechanisms of the Sm-FRF in relation to sulfhydryl (SH) groups, nitric oxide (NO) and antioxidant enzymes were also evaluated. The Sm-FRF (100 mg/kg, p.o.) significantly reduced gastric injury in all models, and did not alter gastric juice parameters after pylorus ligation. The results indicate significant gastroprotective activity for the Sm-FRF, which probably involves the participation of both SH groups and the antioxidant system. Both are integral parts of the gastrointestinal mucosa's cytoprotective mechanisms against aggressive factors.
Subject: Animals
Anti-ulcer Agents
Disease Models, Animal
Gastric Juice
Gastric Mucosa
Mice, Inbred Strains
Nitric Oxide
Plant Extracts
Rats, Wistar
Stomach Ulcer
Sulfhydryl Compounds
Syngonanthus Macrolepsis
Gastroprotective Activity
Medicinal Plants
Citation: The Journal Of Pharmacy And Pharmacology. v. 66, n. 3, p. 445-52, 2014-Mar.
Rights: fechado
Identifier DOI: 10.1111/jphp.12175
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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