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Type: Artigo de periódico
Title: Histologic Correlation Of Expression Of Ki-67 In Squamous Cell Carcinoma Of The Glottis According To The Degree Of Cell Differentiation.
Author: Bonhin, Rodrigo Gonzalez
Carvalho, Guilherme Machado de
Guimarães, Alexandre Caixeta
Chone, Carlos Takahiro
Crespo, Agrício Nubiato
Altemani, Albina Messias de Almeida Milani
Amstalden, Eliane M I
Abstract: Squamous cell carcinoma is the most common neoplasm of the larynx and glottis, and its prognosis depends on the size of the lesion, level of local invasion, cervical lymphatic spread, and presence of distant metastases. Ki-67 (MKI67) is a protein present in the core, whose function is related to cell proliferation. To evaluate the expression of marker Ki-67 in squamous cell carcinoma of the larynx and glottis and its correlation to pathological findings. Experimental study with immunohistochemistry analysis of Ki-67, calculating the percentage of the cell proliferation index in glottic squamous cell carcinomas. Sixteen cases were analyzed, with six well-differentiated and 10 poorly/moderately differentiated tumors. There was a correlation between cell proliferation index and degree of cell differentiation, with higher proliferation in poorly/moderately differentiated tumors. The cell proliferation index, as measured by Ki-67, may be useful in the characterization of histological degree in glottic squamous cell tumors.
Subject: Adult
Carcinoma, Squamous Cell
Cell Differentiation
Cell Proliferation
Cohort Studies
Cross-sectional Studies
Ki-67 Antigen
Laryngeal Neoplasms
Middle Aged
Neoplasm Staging
Predictive Value Of Tests
Tumor Markers, Biological
Biological Markers
Carcinoma De Células Escamosas
Carcinoma, Squamous Cell
Cell Proliferation
Head And Neck Neoplasms
Marcadores Biológicos
Neoplasias De Cabeça E Pescoço
Proliferação De Células
Citation: Brazilian Journal Of Otorhinolaryngology. v. 80, n. 4, p. 290-5
Rights: aberto
Identifier DOI: 10.1016/j.bjorl.2014.05.016
Date Issue: -1-Uns- -1
Appears in Collections:Unicamp - Artigos e Outros Documentos

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