Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/201682
Type: Artigo
Title: Histologic correlation of expression of Ki-67 in squamous cell carcinoma of the glottis according to the degree of cell differentiation
Author: Bonhin, Rodrigo Gonzalez
Carvalho, Guilherme Machado de
Guimarães, Alexandre Caixeta
Chone, Carlos Takahiro
Crespo, Agrício Nubiato
Altemani, Albina Messias de Almeida Milani
Amstalden, Eliane M. I.
Abstract: Squamous cell carcinoma is the most common neoplasm of the larynx and glottis, and its prognosis depends on the size of the lesion, level of local invasion, cervical lymphatic spread, and presence of distant metastases. Ki-67 (MKI67) is a protein present in the core, whose function is related to cell proliferation. To evaluate the expression of marker Ki-67 in squamous cell carcinoma of the larynx and glottis and its correlation to pathological findings. Experimental study with immunohistochemistry analysis of Ki-67, calculating the percentage of the cell proliferation index in glottic squamous cell carcinomas. Sixteen cases were analyzed, with six well-differentiated and 10 poorly/moderately differentiated tumors. There was a correlation between cell proliferation index and degree of cell differentiation, with higher proliferation in poorly/moderately differentiated tumors. The cell proliferation index, as measured by Ki-67, may be useful in the characterization of histological degree in glottic squamous cell tumors.
Squamous cell carcinoma is the most common neoplasm of the larynx and glottis, and its prognosis depends on the size of the lesion, level of local invasion, cervical lymphatic spread, and presence of distant metastases. Ki-67 (MKI67) is a protein present
Subject: Carcinoma de células escamosas
Estudos de coortes
Imuno-histoquímica
Country: Brasil
Editor: Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial
Citation: Brazilian Journal Of Otorhinolaryngology. v. 80, n. 4, p. 290-5
Rights: aberto
Identifier DOI: 10.1016/j.bjorl.2014.05.016
Address: https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S1808869414000342
Date Issue: 2014
Appears in Collections:FCM - Artigos e Outros Documentos

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