Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/201652
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampFaria, Karina Moraispt_BR
dc.contributor.authorunicampGross, Vanessa Cristinapt_BR
dc.contributor.authorunicampAlmeida, Oslei Paes dept_BR
dc.contributor.authorunicampLopes, Márcio Ajudartept_BR
dc.contributor.authorunicampSantos-Silva, Alan Rogerpt_BR
dc.typeArtigopt_BR
dc.titleMicromorphology of the dental pulp is highly preserved in cancer patients who underwent head and neck radiotherapypt_BR
dc.contributor.authorFaria, Karina Moraispt_BR
dc.contributor.authorBrandão, Thais Biancapt_BR
dc.contributor.authorRibeiro, Ana Carolina Pradopt_BR
dc.contributor.authorVasconcellos, Adriele Ferreira Gouvêapt_BR
dc.contributor.authorde Carvalho, Icaro Thiagopt_BR
dc.contributor.authorde Arruda, Fernando Freirept_BR
dc.contributor.authorCastro Junior, Gilbertopt_BR
dc.contributor.authorGross, Vanessa Cristinapt_BR
dc.contributor.authorAlmeida, Oslei Paespt_BR
dc.contributor.authorLopes, Marcio Ajudartept_BR
dc.contributor.authorSantos-Silva, Alan Rogerpt_BR
dc.subjectPolpa dentáriapt_BR
dc.subjectRadioterapiapt_BR
dc.subject.otherlanguageDental pulppt_BR
dc.subject.otherlanguageRadiotherapypt_BR
dc.description.abstractTeeth are often included in the radiation field during head and neck radiotherapy, and recent clinical evidence suggests that dental pulp is negatively affected by the direct effects of radiation, leading to impaired sensitivity of the dental pulp. Therefore, this study aimed to investigate the direct effects of radiation on the microvasculature, innervation, and extracellular matrix of the dental pulp of patientswho have undergone head and neck radiotherapy. Twenty-three samples of dental pulp from patients who finished head and neck radiotherapy were analyzed. Samples were histologically processed and stained with hematoxylin-eosin for morphologic evaluation of the microvasculature, innervation, and extracellular matrix. Subsequently, immunohistochemical analysis of proteins related to vascularization (CD34 and smooth muscle actin), innervation (S-100, NCAM/CD56, and neurofilament), and extracellular matrix (vimentin) of the dental pulp was performed. The morphologic study identified preservation of the microvasculature, nerve bundles, and components of the extracellular matrix in all studied samples. The immunohistochemical analysis confirmed the morphologic findings and showed a normal pattern of expression for the studied proteins in all samples. Direct effects of radiotherapy are not able to generate morphologic changes in the microvasculature, innervation, and extracellular matrix components of the dental pulp in head and neck cancer patientspt
dc.relation.ispartofJournal of endodonticspt_BR
dc.relation.ispartofabbreviationJ. endod.pt_BR
dc.publisher.cityPhiladelphia, PApt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2014pt_BR
dc.date.monthofcirculationOct.pt_BR
dc.identifier.citationJournal Of Endodontics. v. 40, n. 10, p. 1553-9, 2014-Oct.pt_BR
dc.language.isoengpt_BR
dc.description.volume40pt_BR
dc.description.issuenumber10pt_BR
dc.description.firstpage1553pt_BR
dc.description.lastpage1559pt_BR
dc.rightsfechadopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn0099-2399pt_BR
dc.identifier.eissn1878-3554pt_BR
dc.identifier.doi10.1016/j.joen.2014.07.006pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0099239914006402pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsorship1FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOpt_BR
dc.description.sponsorship1CAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL E NÍVEL SUPERIORpt_BR
dc.description.sponsorship1CNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOpt_BR
dc.description.sponsordocumentnumber2013/18402-8; 2012/06138-1pt_BR
dc.description.sponsordocumentnumber758/2012pt_BR
dc.description.sponsordocumentnumber474697/2012-6; 122167/2012-0pt_BR
dc.date.available2015-11-27T13:43:11Z-
dc.date.accessioned2015-11-27T13:43:11Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:43:11Z (GMT). No. of bitstreams: 1 pmed_25150372.pdf: 2593598 bytes, checksum: 0eb1c24ad96c65496d786ae42f9c0473 (MD5) Previous issue date: 2014 Bitstreams deleted on 2020-05-14T20:38:52Z: pmed_25150372.pdf,. Added 1 bitstream(s) on 2020-05-14T20:43:12Z : No. of bitstreams: 1 25150372.pdf: 475759 bytes, checksum: 9e75acb7fd28dd0b8b573bfd383e6312 (MD5) Bitstreams deleted on 2020-06-04T12:48:05Z: 25150372.pdf,. Added 1 bitstream(s) on 2020-06-04T12:53:16Z : No. of bitstreams: 1 25150372.pdf: 3078446 bytes, checksum: 83244c962edc98955f9ae07630e658fd (MD5)en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201652-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Diagnóstico Oralpt_BR
dc.contributor.departmentDepartamento de Diagnóstico Oralpt_BR
dc.contributor.departmentDepartamento de Diagnóstico Oralpt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.subject.keywordCancerpt_BR
dc.subject.keywordRadiation cariespt_BR
dc.subject.keywordSide effectspt_BR
dc.identifier.source25150372-
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0001-6677-0065pt_BR
dc.creator.orcid0000-0003-2040-6617pt_BR
dc.type.formArtigopt_BR
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