Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/201652
Type: Artigo de periódico
Title: Micromorphology Of The Dental Pulp Is Highly Preserved In Cancer Patients Who Underwent Head And Neck Radiotherapy.
Author: Faria, Karina Morais
Brandão, Thais Bianca
Ribeiro, Ana Carolina Prado
Vasconcellos, Adriele Ferreira Gouvêa
de Carvalho, Icaro Thiago
de Arruda, Fernando Freire
Castro Junior, Gilberto
Gross, Vanessa Cristina
Almeida, Oslei Paes
Lopes, Marcio Ajudarte
Santos-Silva, Alan Roger
Abstract: Teeth are often included in the radiation field during head and neck radiotherapy, and recent clinical evidence suggests that dental pulp is negatively affected by the direct effects of radiation, leading to impaired sensitivity of the dental pulp. Therefore, this study aimed to investigate the direct effects of radiation on the microvasculature, innervation, and extracellular matrix of the dental pulp of patients who have undergone head and neck radiotherapy. Twenty-three samples of dental pulp from patients who finished head and neck radiotherapy were analyzed. Samples were histologically processed and stained with hematoxylin-eosin for morphologic evaluation of the microvasculature, innervation, and extracellular matrix. Subsequently, immunohistochemical analysis of proteins related to vascularization (CD34 and smooth muscle actin), innervation (S-100, NCAM/CD56, and neurofilament), and extracellular matrix (vimentin) of the dental pulp was performed. The morphologic study identified preservation of the microvasculature, nerve bundles, and components of the extracellular matrix in all studied samples. The immunohistochemical analysis confirmed the morphologic findings and showed a normal pattern of expression for the studied proteins in all samples. Direct effects of radiotherapy are not able to generate morphologic changes in the microvasculature, innervation, and extracellular matrix components of the dental pulp in head and neck cancer patients.
Subject: Cancer
Dental Pulp
Radiation Caries
Radiotherapy
Side Effects
Rights: fechado
Identifier DOI: 10.1016/j.joen.2014.07.006
Address: http://www.ncbi.nlm.nih.gov/pubmed/25150372
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
pmed_25150372.pdf2.53 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.