Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/201604
Type: Artigo de periódico
Title: Antimicrobial And Antiproliferative Potential Of Anadenanthera Colubrina (vell.) Brenan.
Author: Lima, Rennaly de Freitas
Alves, Erika Ponchet
Rosalen, Pedro Luiz
Ruiz, Ana Lúcia Tasca Gois
Teixeira Duarte, Marta Cristina
Góes, Vivian Fernandes Furletti
de Medeiros, Ana Cláudia Dantas
Pereira, Jozinete Vieira
Godoy, Gustavo Pina
Melo de Brito Costa, Edja Maria
Abstract: The aim of the present study was to perform an in vitro analysis of the antimicrobial and antiproliferative potential of an extract from Anadenanthera colubrina (Vell.) Brenan (angico) and chemically characterize the crude extract. Antimicrobial action was evaluated based on the minimum inhibitory concentration (MIC), minimum bactericidal/fungicidal concentration, and the inhibition of formation to oral biofilm. Cell morphology was determined through scanning electron microscopy (SEM). Six strains of tumor cells were used for the determination of antiproliferative potential. The extract demonstrated strong antifungal activity against Candida albicans ATCC 18804 (MIC = 0.031 mg/mL), with similar activity found regarding the ethyl acetate fraction. The extract and active fraction also demonstrated the capacity to inhibit the formation of Candida albicans to oral biofilm after 48 hours, with median values equal to or greater than the control group, but the difference did not achieve statistical significance (P > 0.05). SEM revealed alterations in the cell morphology of the yeast. Regarding antiproliferative activity, the extract demonstrated cytostatic potential in all strains tested. The present findings suggest strong antifungal potential for Anadenanthera colubrina (Vell.) Brenan as well as a tendency toward diminishing the growth of human tumor cells.
Rights: aberto
Identifier DOI: 10.1155/2014/802696
Address: http://www.ncbi.nlm.nih.gov/pubmed/25093029
Date Issue: 2014
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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