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Type: Artigo de periódico
Title: Metals And (metallo)proteins Identification In Vitreous Humor Focusing On Post-mortem Biochemistry.
Author: Santos Júnior, Júlio César
Mollo Filho, Pedro Carlos
Felice Guidugli, Ruggero Bernardo
Eberlin, Marcos Nogueira
Pessôa, Gustavo de Souza
da Silva, Elidiane Gomes
Arruda, Marco Aurélio Zezzi
Höehr, Nelci Fenalti
Abstract: This work describes the evaluation of metals and (metallo)proteins in vitreous humor samples and their correlations with some biological aspects in different post-mortem intervals (1-7 days), taking into account both decomposing and non-decomposing bodies. After qualitative evaluation of the samples involving 26 elements, representative metal ions (Fe, Mg and Mo) are determined by inductively coupled plasma mass spectrometry after using mini-vial decomposition system for sample preparation. A significant trend for Fe is found with post-mortem time for decomposing bodies because of a significant increase of iron concentration when comparing samples from bodies presenting 3 and 7 days post-mortem interval. An important clue to elucidate the role of metals is the coupling of liquid chromatography with inductively coupled plasma mass spectrometry for identification of metals linked to proteins, as well as mass spectrometry for the identification of those proteins involved in the post-mortem interval.
Citation: Metallomics : Integrated Biometal Science. v. 6, n. 10, p. 1801-7, 2014-Oct.
Rights: aberto
Identifier DOI: 10.1039/c3mt00373f
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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