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Type: Artigo de periódico
Title: Matrix Metalloproteinases And Left Ventricular Function And Structure In Spinal Cord Injured Subjects.
Author: Schreiber, Roberto
Paim, Layde R
de Rossi, Guilherme
Matos-Souza, José R
Costa E Silva, Anselmo de A
Souza, Cristiane M
Borges, Mariane
Azevedo, Eliza R
Alonso, Karina C
Gorla, José I
Cliquet, Alberto
Nadruz, Wilson
Abstract: Subjects with spinal cord injury (SCI) exhibit impaired left ventricular (LV) diastolic function, which has been reported to be attenuated by regular physical activity. This study investigated the relationship between circulating matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) and echocardiographic parameters in SCI subjects and the role of physical activity in this regard. Forty-two men with SCI [19 sedentary (S-SCI) and 23 physically-active (PA-SCI)] were evaluated by clinical, anthropometric, laboratory, and echocardiographic analysis. Plasmatic pro-MMP-2, MMP-2, MMP-8, pro-MMP-9, MMP-9, TIMP-1 and TIMP-2 levels were determined by enzyme-linked immunosorbent assay and zymography. PA-SCI subjects presented lower pro-MMP-2 and pro-MMP-2/TIMP-2 levels and improved markers of LV diastolic function (lower E/Em and higher Em and E/A values) than S-SCI ones. Bivariate analysis showed that pro-MMP-2 correlated inversely with Em and directly with E/Em, while MMP-9 correlated directly with LV mass index and LV end-diastolic diameter in the whole sample. Following multiple regression analysis, pro-MMP-2, but not physical activity, remained associated with Em, while MMP-9 was associated with LV mass index in the whole sample. These findings suggest differing roles for MMPs in LV structure and function regulation and an interaction among pro-MMP-2, diastolic function and physical activity in SCI subjects.
Subject: Exercise
Matrix Metalloproteinase
Citation: Clinica Chimica Acta; International Journal Of Clinical Chemistry. v. 437, p. 136-40, 2014-Nov.
Rights: fechado
Identifier DOI: 10.1016/j.cca.2014.07.018
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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