Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/201527
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleThe Consequences Of Refractory Epilepsy And Its Treatment.pt_BR
dc.contributor.authorLaxer, Kenneth Dpt_BR
dc.contributor.authorTrinka, Eugenpt_BR
dc.contributor.authorHirsch, Lawrence Jpt_BR
dc.contributor.authorCendes, Fernandopt_BR
dc.contributor.authorLangfitt, Johnpt_BR
dc.contributor.authorDelanty, Normanpt_BR
dc.contributor.authorResnick, Trevorpt_BR
dc.contributor.authorBenbadis, Selim Rpt_BR
unicamp.authorFernando Cendes, Department of Neurology, University of Campinas (UNICAMP), Campinas, Brazil.pt_BR
unicamp.author.externalKenneth D Laxer, Sutter Pacific Epilepsy Program, California Pacific Medical Center, San Francisco, CA, USA. Electronic address: laxerkd@sutterhealth.org.pt
unicamp.author.externalEugen Trinka, Department of Neurology, Christian Doppler Medical Centre, Paracelsus Medical University, Salzburg, Austriapt
unicamp.author.externalCentre for Cognitive Neuroscience, Salzburg, Austria.pt
unicamp.author.externalLawrence J Hirsch, Division of Epilepsy and EEG, Department of Neurology, Yale Comprehensive Epilepsy Center, New Haven, CT, USA.pt
unicamp.author.externalJohn Langfitt, Department of Neurology, University of Rochester School of Medicine, Rochester, NY, USApt
unicamp.author.externalDepartment Psychiatry, University of Rochester School of Medicine, Rochester, NY, USApt
unicamp.author.externalStrong Epilepsy Center, University of Rochester School of Medicine, Rochester, NY, USA.pt
unicamp.author.externalNorman Delanty, Epilepsy Service and National Epilepsy Surgery Programme, Beaumont Hospital, Dublin, Ireland.pt
unicamp.author.externalTrevor Resnick, Comprehensive Epilepsy Program, Miami Children's Hospital, Miami, FL, USA.pt
unicamp.author.externalSelim R Benbadis, Comprehensive Epilepsy Program, University of South Florida, Tampa, FL, USA.pt
dc.subjectAntiepileptic Treatmentpt_BR
dc.subjectComorbiditiespt_BR
dc.subjectEpilepsypt_BR
dc.subjectMortalitypt_BR
dc.subjectSafetypt_BR
dc.subjectSudden Unexpected Death In Epilepsypt_BR
dc.description.abstractSeizures in some 30% to 40% of patients with epilepsy fail to respond to antiepileptic drugs or other treatments. While much has been made of the risks of new drug therapies, not enough attention has been given to the risks of uncontrolled and progressive epilepsy. This critical review summarizes known risks associated with refractory epilepsy, provides practical clinical recommendations, and indicates areas for future research. Eight international epilepsy experts from Europe, the United States, and South America met on May 4, 2013, to present, review, and discuss relevant concepts, data, and literature on the consequences of refractory epilepsy. While patients with refractory epilepsy represent the minority of the population with epilepsy, they require the overwhelming majority of time, effort, and focus from treating physicians. They also represent the greatest economic and psychosocial burdens. Diagnostic procedures and medical/surgical treatments are not without risks. Overlooked, however, is that these risks are usually smaller than the risks of long-term, uncontrolled seizures. Refractory epilepsy may be progressive, carrying risks of structural damage to the brain and nervous system, comorbidities (osteoporosis, fractures), and increased mortality (from suicide, accidents, sudden unexpected death in epilepsy, pneumonia, vascular disease), as well as psychological (depression, anxiety), educational, social (stigma, driving), and vocational consequences. Adding to this burden is neuropsychiatric impairment caused by underlying epileptogenic processes (essential comorbidities), which appears to be independent of the effects of ongoing seizures themselves. Tolerating persistent seizures or chronic medicinal adverse effects has risks and consequences that often outweigh risks of seemingly more aggressive treatments. Future research should focus not only on controlling seizures but also on preventing these consequences.en
dc.relation.ispartofEpilepsy & Behavior : E&bpt_BR
dc.relation.ispartofabbreviationEpilepsy Behavpt_BR
dc.date.issued2014-Augpt_BR
dc.identifier.citationEpilepsy & Behavior : E&b. v. 37, p. 59-70, 2014-Aug.pt_BR
dc.language.isoengpt_BR
dc.description.volume37pt_BR
dc.description.firstpage59-70pt_BR
dc.rightsfechadopt_BR
dc.rights.holderCopyright © 2014. Published by Elsevier Inc.pt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1525-5069pt_BR
dc.identifier.doi10.1016/j.yebeh.2014.05.031pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/24980390pt_BR
dc.date.available2015-11-27T13:42:51Z-
dc.date.accessioned2015-11-27T13:42:51Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:42:51Z (GMT). No. of bitstreams: 1 pmed_24980390.pdf: 681039 bytes, checksum: 7ce7b32f809d75a7c575407e1dbed963 (MD5) Previous issue date: 2014en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201527-
dc.identifier.idPubmed24980390pt_BR
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
pmed_24980390.pdf665.08 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.