Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/201509
Type: Artigo de periódico
Title: Hypothalamic Inflammation And The Central Nervous System Control Of Energy Homeostasis.
Author: Pimentel, Gustavo D
Ganeshan, Kirthana
Carvalheira, José B C
Abstract: The control of energy homeostasis relies on robust neuronal circuits that regulate food intake and energy expenditure. Although the physiology of these circuits is well understood, the molecular and cellular response of this program to chronic diseases is still largely unclear. Hypothalamic inflammation has emerged as a major driver of energy homeostasis dysfunction in both obesity and anorexia. Importantly, this inflammation disrupts the action of metabolic signals promoting anabolism or supporting catabolism. In this review, we address the evidence that favors hypothalamic inflammation as a factor that resets energy homeostasis in pathological states.
Subject: Cancer
Cytokines
Hypothalamus
Inflammation
Obesity
Peripheral Tissues
Rights: fechado
Identifier DOI: 10.1016/j.mce.2014.06.005
Address: http://www.ncbi.nlm.nih.gov/pubmed/24952114
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
pmed_24952114.pdf594.22 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.