Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/201477
Type: Artigo de periódico
Title: Longitudinal Analysis Of Hippocampal T2 Relaxometry In Fmtle.
Author: Suemitsu, Luciana Akemi Yasuda
Yasuda, Clarissa Lin
Morita, Marcia Elisabete
Beltramini, Guilherme Coco
Coan, Ana Carolina
Bergo, Felipe
Lopes-Cendes, Iscia
Cendes, Fernando
Abstract: To investigate the degree of T2 relaxometry changes over time in groups of patients with familial mesial temporal lobe epilepsy (FMTLE) and asymptomatic relatives. We conducted both cross-sectional and longitudinal analyses of T2 relaxometry with Aftervoxel, an in-house software for medical image visualization. The cross-sectional study included 35 subjects (26 with FMTLE and 9 asymptomatic relatives) and 40 controls; the longitudinal study was composed of 30 subjects (21 with FMTLE and 9 asymptomatic relatives; the mean time interval of MRIs was 4.4 ± 1.5 years) and 16 controls. To increase the size of our groups of patients and relatives, we combined data acquired in 2 scanners (2T and 3T) and obtained z-scores using their respective controls. General linear model on SPSS21® was used for statistical analysis. In the cross-sectional analysis, elevated T2 relaxometry was identified for subjects with seizures and intermediate values for asymptomatic relatives compared to controls. Subjects with MRI signs of hippocampal sclerosis presented elevated T2 relaxometry in the ipsilateral hippocampus, while patients and asymptomatic relatives with normal MRI presented elevated T2 values in the right hippocampus. The longitudinal analysis revealed a significant increase in T2 relaxometry for the ipsilateral hippocampus exclusively in patients with seizures. The longitudinal increase of T2 signal in patients with seizures suggests the existence of an interaction between ongoing seizures and the underlying pathology, causing progressive damage to the hippocampus. The identification of elevated T2 relaxometry in asymptomatic relatives and in patients with normal MRI suggests that genetic factors may be involved in the development of some mild hippocampal abnormalities in FMTLE.
Subject: Adult
Cross-sectional Studies
Electroencephalography
Epilepsy, Temporal Lobe
Female
Functional Laterality
Hippocampus
Humans
Image Processing, Computer-assisted
Longitudinal Studies
Magnetic Resonance Imaging
Male
Middle Aged
Multivariate Analysis
Familial Mesial Temporal Lobe Epilepsy
Longitudinal Analysis
Magnetic Resonance Imaging
T2 Relaxometry
Rights: fechado
Identifier DOI: 10.1016/j.yebeh.2014.05.023
Address: http://www.ncbi.nlm.nih.gov/pubmed/24926943
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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