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Type: Artigo de periódico
Title: Identification Of Target Genes Using Gene Expression Profile Of Granulocytes From Patients With Chronic Myeloid Leukemia Treated With Tyrosine Kinase Inhibitors.
Author: Mascarenhas, Cintia do Couto
Ferreira da Cunha, Anderson
Brugnerotto, Ana Flávia
Gambero, Sheley
de Almeida, Maria Helena
Carazzolle, Marcelo F
Pagnano, Katia Borgia Barbosa
Traina, Fabíola
Costa, Fernando Ferreira da
de Souza, Carmino Antonio
Abstract: Differential gene expression analysis by suppression subtractive hybridization with correlation to the metabolic pathways involved in chronic myeloid leukemia (CML) may provide a new insight into the pathogenesis of CML. Among the overexpressed genes found in CML at diagnosis are SEPT5, RUNX1, MIER1, KPNA6 and FLT3, while PAN3, TOB1 and ITCH were decreased when compared to healthy volunteers. Some genes were identified and involved in CML for the first time, including TOB1, which showed a low expression in patients with CML during tyrosine kinase inhibitor treatment with no complete cytogenetic response. In agreement, reduced expression of TOB1 was also observed in resistant patients with CML compared to responsive patients. This might be related to the deregulation of apoptosis and the signaling pathway leading to resistance. Most of the identified genes were related to the regulation of nuclear factor κB (NF-κB), AKT, interferon and interleukin-4 (IL-4) in healthy cells. The results of this study combined with literature data show specific gene pathways that might be explored as markers to assess the evolution and prognosis of CML as well as identify new therapeutic targets.
Subject: Chronic Myeloid Leukemia
Suppression Subtractive Hybridization
Tyrosine Kinase Inhibitors
Citation: Leukemia & Lymphoma. v. 55, n. 8, p. 1861-9, 2014-Aug.
Rights: fechado
Identifier DOI: 10.3109/10428194.2013.855311
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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