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Type: Artigo de periódico
Title: Nat2, Xrcc1 And Hogg1 Polymorphisms, Cigarette Smoking, Alcohol Consumption And Risk Of Upper Aerodigestive Tract Cancer.
Author: Marques, Cintia Rodrigues
Da Silva, Thiago Magalhães
De Albuquerque, Dulcineia Martins
Chaves, Meiryane Santos
Marques Filho, Marcilio Ferreira
Oliveira, Jamille Silva
Di Pietro, Giuliano
Sousa, Sandra Mara Bispo
Simões, Aguinaldo Luiz
Rios-Santos, Fabrício
Abstract: To evaluate associations between polymorphisms of the N-acetyltransferase 2 (NAT2), human 8-oxoguanine glycosylase 1 (hOGG1) and X-ray repair cross-complementing protein 1 (XRCC1) genes and risk of upper aerodigestive tract (UADT) cancer. A case-control study involving 117 cases and 224 controls was undertaken. The NAT2 gene polymorphisms were genotyped by automated sequencing and XRCC1 Arg399Gln and hOGG1 Ser326Cys polymorphisms were determined by Polymerase Chain Reaction followed by Restriction Fragment Length Polymorphism (PCR-RFLP) methods. Slow metabolization phenotype was significantly associated as a risk factor for the development of UADT cancer (p=0.038). Furthermore, haplotype of slow metabolization was also associated with UADT cancer (p=0.014). The hOGG1 Ser326Cys polymorphism (CG or GG vs. CC genotypes) was shown as a protective factor against UADT cancer in moderate smokers (p=0.031). The XRCC1 Arg399Gln polymorphism (GA or AA vs. GG genotypes), in turn, was a protective factor against UADT cancer only among never-drinkers (p=0.048). Interactions involving NAT2, XRCC1 Arg399Gln and hOGG1 Ser326Cys polymorphisms may modulate the risk of UADT cancer in this population.
Subject: Aged
Alcohol Drinking
Arylamine N-acetyltransferase
Case-control Studies
Dna Glycosylases
Dna-binding Proteins
Follow-up Studies
Gastrointestinal Neoplasms
Middle Aged
Neoplasm Staging
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide
Respiratory Tract Neoplasms
Risk Factors
Dna Repair
Uadt Cancer
Alcohol Drinking
Genetic Epidemiology
Rights: fechado
Identifier DOI: 
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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