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Type: Artigo de periódico
Title: Bleeding Complications In Dengue Are Not Associated With Significant Changes In The Modulators Of The Endothelial Barrier.
Author: Orsi, Fernanda Andrade
Angerami, Rodrigo Nogueira
Mazetto, Bruna Moraes
Quaino, Susan Kelly Picoli
De Paula, Erich Vinícius
Annichino-Bizzachi, Joyce Maria
Abstract: Bleeding complications in dengue may occur irrespective of the presence of plasma leakage. We compared plasma levels of modulators of the endothelial barrier among three dengue groups: bleedings without plasma leakage, dengue hemorrhagic fever, and non-complicated dengue. The aim was to evaluate whether the presence of subtle alterations in microvascular permeability could be detected in bleeding patients. Plasma levels of VEGF-A and its soluble receptors were not associated with the occurrence of bleeding in patients without plasma leakage. These results provide additional rationale for considering bleeding as a complication independent of endothelial barrier breakdown, as proposed by the 2009 WHO classification.
Rights: aberto
Identifier DOI: 
Date Issue: 2014
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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