Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/201466
Type: Artigo de periódico
Title: A Highly Improved Method For Sensitive Determination Of Amitriptyline In Pharmaceutical Formulations Using An Unmodified Carbon Nanotube Electrode In The Presence Of Sulfuric Acid.
Author: Duarte, Eduardo Henrique
dos Santos, William Pereira
Hudari, Felipe Fantinato
Bott Neto, José Luiz
Sartori, Elen Romão
Dall'Antonia, Luiz Henrique
Pereira, Arnaldo César
Tarley, César Ricardo Teixeira
Abstract: The present paper describes a novel, simple and reliable differential pulse voltammetric method for determining amitriptyline (AMT) in pharmaceutical formulations. It has been described for many authors that this antidepressant is electrochemically inactive at carbon electrodes. However, the procedure proposed herein consisted in electrochemically oxidizing AMT at an unmodified carbon nanotube paste electrode in the presence of 0.1 mol L(-1) sulfuric acid used as electrolyte. At such concentration, the acid facilitated the AMT electroxidation through one-electron transfer at 1.33 V vs. Ag/AgCl, as observed by the augmentation of peak current. Concerning optimized conditions (modulation time 5 ms, scan rate 90 mV s(-1), and pulse amplitude 120 mV) a linear calibration curve was constructed in the range of 0.0-30.0 μmol L(-1), with a correlation coefficient of 0.9991 and a limit of detection of 1.61 μmol L(-1). The procedure was successfully validated for intra- and inter-day precision and accuracy. Moreover, its feasibility was assessed through analysis of commercial pharmaceutical formulations and it has been compared to the UV-vis spectrophotometric method used as standard analytical technique recommended by the Brazilian Pharmacopoeia.
Subject: Carbon Nanotube Paste Electrode
Differential Pulse Voltammetry
Sulfuric Acid Medium
Tricyclic Antidepressants
Rights: fechado
Identifier DOI: 10.1016/j.talanta.2014.03.068
Address: http://www.ncbi.nlm.nih.gov/pubmed/24913853
Date Issue: 2014
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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