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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleHepatic Involvement In Paediatric Patients With Paracoccidioidomycosis: A Histological Study.pt_BR
dc.contributor.authorde Melo Braga, Gisellept_BR
dc.contributor.authorHessel, Gabrielpt_BR
dc.contributor.authorPereira, Ricardo Mendespt_BR
dc.contributor.authorEscanhoela, Cecília Amélia Fazziopt_BR
unicamp.authorGiselle de Melo Braga, Center for Investigation in Pediatrics, UNICAMP School of Medicine, Campinas, Brazil.pt_BR
unicamp.author.externalGabriel Hessel,pt
unicamp.author.externalRicardo Mendes Pereira,pt
unicamp.author.externalCecília Amélia Fazzio Escanhoela,pt
dc.subjectAdolescentpt_BR
dc.subjectChildpt_BR
dc.subjectChild, Preschoolpt_BR
dc.subjectFemalept_BR
dc.subjectHumanspt_BR
dc.subjectKeratin-19pt_BR
dc.subjectKeratin-7pt_BR
dc.subjectLiverpt_BR
dc.subjectMalept_BR
dc.subjectParacoccidioidomycosispt_BR
dc.subjectBile Ductspt_BR
dc.subjectImmunohistochemistrypt_BR
dc.subjectLiverpt_BR
dc.subjectPaediatricspt_BR
dc.subjectParacoccidioidomycosispt_BR
dc.description.abstractParacoccidioidomycosis is a systemic mycosis that is endemic to certain countries in Latin America. This study aimed to describe the histological features of liver involvement in patients with paracoccidioidomycosis aged <16 years of age who were treated between 1980 and 2010, with a diagnosis that was confirmed by detection of the fungus by pathological examination. Liver tissue was obtained from one necropsy and 12 biopsies. Throughout 2007, biopsies were taken from patients with persistent jaundice or portal hypertension, after which biopsies became indicated due to elevated aminotransferase and low albumin levels. Using haematoxylin and eosin (H&E), Masson's trichrome and immunohistochemical (CK7 and CK19) staining, we noted degenerative alterations in bile duct cells and inflammatory injury to the bile ducts in 10 biopsies. Using immunohistochemistry for CK7 and CK19, we observed ductal proliferation in all 12 samples. Bile duct injuries by inflammatory cells might explain the predominant increase in canalicular enzymes; immunohistochemistry is more sensitive in demonstrating ductular reactions and might show changes that are not apparent on H&E staining.en
dc.relation.ispartofHistopathologypt_BR
dc.relation.ispartofabbreviationHistopathologypt_BR
dc.date.issued2014-Janpt_BR
dc.identifier.citationHistopathology. v. 64, n. 2, p. 256-62, 2014-Jan.pt_BR
dc.language.isoengpt_BR
dc.description.volume64pt_BR
dc.description.firstpage256-62pt_BR
dc.rightsfechadopt_BR
dc.rights.holder© 2013 John Wiley & Sons Ltd.pt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1365-2559pt_BR
dc.identifier.doi10.1111/his.12244pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/24117867pt_BR
dc.date.available2015-11-27T13:42:39Z-
dc.date.accessioned2015-11-27T13:42:39Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:42:39Z (GMT). No. of bitstreams: 1 pmed_24117867.pdf: 708844 bytes, checksum: 8e7f9a88e130fad8c0a1cec4620b2c1e (MD5) Previous issue date: 2014en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201441-
dc.identifier.idPubmed24117867pt_BR
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