Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/201441
Type: Artigo de periódico
Title: Hepatic Involvement In Paediatric Patients With Paracoccidioidomycosis: A Histological Study.
Author: de Melo Braga, Giselle
Hessel, Gabriel
Pereira, Ricardo Mendes
Escanhoela, Cecília Amélia Fazzio
Abstract: Paracoccidioidomycosis is a systemic mycosis that is endemic to certain countries in Latin America. This study aimed to describe the histological features of liver involvement in patients with paracoccidioidomycosis aged <16 years of age who were treated between 1980 and 2010, with a diagnosis that was confirmed by detection of the fungus by pathological examination. Liver tissue was obtained from one necropsy and 12 biopsies. Throughout 2007, biopsies were taken from patients with persistent jaundice or portal hypertension, after which biopsies became indicated due to elevated aminotransferase and low albumin levels. Using haematoxylin and eosin (H&E), Masson's trichrome and immunohistochemical (CK7 and CK19) staining, we noted degenerative alterations in bile duct cells and inflammatory injury to the bile ducts in 10 biopsies. Using immunohistochemistry for CK7 and CK19, we observed ductal proliferation in all 12 samples. Bile duct injuries by inflammatory cells might explain the predominant increase in canalicular enzymes; immunohistochemistry is more sensitive in demonstrating ductular reactions and might show changes that are not apparent on H&E staining.
Subject: Adolescent
Child
Child, Preschool
Female
Humans
Keratin-19
Keratin-7
Liver
Male
Paracoccidioidomycosis
Bile Ducts
Immunohistochemistry
Liver
Paediatrics
Paracoccidioidomycosis
Citation: Histopathology. v. 64, n. 2, p. 256-62, 2014-Jan.
Rights: fechado
Identifier DOI: 10.1111/his.12244
Address: http://www.ncbi.nlm.nih.gov/pubmed/24117867
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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