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Type: Artigo de periódico
Title: Integrated Proteomics Identified Up-regulated Focal Adhesion-mediated Proteins In Human Squamous Cell Carcinoma In An Orthotopic Murine Model.
Author: Granato, Daniela C
Zanetti, Mariana R
Kawahara, Rebeca
Yokoo, Sami
Domingues, Romênia R
Aragão, Annelize Z
Agostini, Michelle
Carazzolle, Marcelo F
Vidal, Ramon O
Flores, Isadora L
Korvala, Johanna
Cervigne, Nilva K
Silva, Alan R S
Coletta, Ricardo D
Graner, Edgard
Sherman, Nicholas E
Paes Leme, Adriana F
Abstract: Understanding the molecular mechanisms of oral carcinogenesis will yield important advances in diagnostics, prognostics, effective treatment, and outcome of oral cancer. Hence, in this study we have investigated the proteomic and peptidomic profiles by combining an orthotopic murine model of oral squamous cell carcinoma (OSCC), mass spectrometry-based proteomics and biological network analysis. Our results indicated the up-regulation of proteins involved in actin cytoskeleton organization and cell-cell junction assembly events and their expression was validated in human OSCC tissues. In addition, the functional relevance of talin-1 in OSCC adhesion, migration and invasion was demonstrated. Taken together, this study identified specific processes deregulated in oral cancer and provided novel refined OSCC-targeting molecules.
Citation: Plos One. v. 9, n. 5, p. e98208, 2014.
Rights: aberto
Identifier DOI: 10.1371/journal.pone.0098208
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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