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Type: Artigo de periódico
Title: Testosterone Therapy Differently Regulates The Anti- And Pro-inflammatory Cytokines In The Plasma And Prostate Of Rats Submitted To Chronic Ethanol Consumption (uchb).
Author: Mendes, Leonardo Oiveira
Scarano, Wellerson Rodrigo
Rochel-Maia, Sabrina Santos
Fioruci-Fontaneli, Beatriz Aparecida
Chuffa, Luiz Gustavo Almeida
Martinez, Francisco Eduardo
Abstract: Ethanol consumption damages the prostate, and testosterone is known by anti-inflammatory role. The cytokines were investigated in the plasma and ventral prostate of UChB rats submitted or not to testosterone therapy by ELISA and Western blot, respectively. Additionally, inflammatory foci and mast cells were identified in the ventral prostate slides stained by hematoxylin and eosin and toluidine blue, respectively. Inflammatory foci were found in the ethanol-treated animals and absent after testosterone therapy. Plasma levels of IL-6 and IL-10 were not changed while TNFα and TFG-β1 were increased in the animals submitted testosterone therapy. Regarding to ventral prostate, IL-6 did not alter, while IL-10, TNFα, and TFG-β1 were increased after testosterone therapy. Ethanol increases NFR2 in addition to high number of intact and degranulated mast cell which were reduced after testosterone therapy. So, ethanol and testosterone differentially modulates the cytokines in the plasma and prostate.
Subject: Cytokines
Citation: American Journal Of Reproductive Immunology (new York, N.y. : 1989). v. 72, n. 3, p. 317-25, 2014-Sep.
Rights: fechado
Identifier DOI: 10.1111/aji.12268
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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