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Type: Artigo de periódico
Title: The Intrahippocampal Infusion Of Crotamine From Crotalus Durissus Terrificus Venom Enhances Memory Persistence In Rats.
Author: Vargas, Liane S
Lara, Marcus V S
Gonçalves, Rithiele
Mandredini, Vanusa
Ponce-Soto, Luis Alberto
Marangoni, Sergio
Dal Belo, Cháriston A
Mello-Carpes, Pâmela B
Abstract: Previous research has shown that crotamine, a toxin isolated from the venom of Crotalus durissus terrificus, induces the release of acetylcholine and dopamine in the central nervous system of rats. Particularly, these neurotransmitters are important modulators of memory processes. Therefore, in this study we investigated the effects of crotamine infusion on persistence of memory in rats. We verified that the intrahippocampal infusion of crotamine (1 μg/μl; 1 μl/side) improved the persistence of object recognition and aversive memory. By other side, the intrahippocampal infusion of the toxin did not alter locomotor and exploratory activities, anxiety or pain threshold. These results demonstrate a future prospect of using crotamine as potential pharmacological tool to treat diseases involving memory impairment, although it is still necessary more researches to better elucidate the crotamine effects on hippocampus and memory.
Subject: Animals
Avoidance Learning
Behavior, Animal
Ca1 Region, Hippocampal
Crotalid Venoms
Exploratory Behavior
Infusions, Intraventricular
Maze Learning
Memory, Long-term
Motor Activity
Nootropic Agents
Pain Threshold
Rats, Wistar
Recognition (psychology)
Inhibitory Avoidance Memory
Object Recognition Memory
Snake Venom
Rights: fechado
Identifier DOI: 10.1016/j.toxicon.2014.04.017
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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