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Type: Artigo de periódico
Title: Prognostic Value Of Dna And Mrna E6/e7 Of Human Papillomavirus In The Evolution Of Cervical Intraepithelial Neoplasia Grade 2.
Author: Discacciati, Michelle G
da Silva, Ismael Dcg
Villa, Luisa L
Reis, Leandro
Hayashi, Priscila
Costa, Maria C
Rabelo-Santos, Silvia H
Zeferino, Luiz C
Abstract: This study aimed at evaluating whether human papillomavirus (HPV) groups and E6/E7 mRNA of HPV 16, 18, 31, 33, and 45 are prognostic of cervical intraepithelial neoplasia (CIN) 2 outcome in women with a cervical smear showing a low-grade squamous intraepithelial lesion (LSIL). This cohort study included women with biopsy-confirmed CIN 2 who were followed up for 12 months, with cervical smear and colposcopy performed every three months. Women with a negative or low-risk HPV status showed 100% CIN 2 regression. The CIN 2 regression rates at the 12-month follow-up were 69.4% for women with alpha-9 HPV versus 91.7% for other HPV species or HPV-negative status (P < 0.05). For women with HPV 16, the CIN 2 regression rate at the 12-month follow-up was 61.4% versus 89.5% for other HPV types or HPV-negative status (P < 0.05). The CIN 2 regression rate was 68.3% for women who tested positive for HPV E6/E7 mRNA versus 82.0% for the negative results, but this difference was not statistically significant. The expectant management for women with biopsy-confirmed CIN 2 and previous cytological tests showing LSIL exhibited a very high rate of spontaneous regression. HPV 16 is associated with a higher CIN 2 progression rate than other HPV infections. HPV E6/E7 mRNA is not a prognostic marker of the CIN 2 clinical outcome, although this analysis cannot be considered conclusive. Given the small sample size, this study could be considered a pilot for future larger studies on the role of predictive markers of CIN 2 evolution.
Subject: E6 Protein
Cervical Intraepithelial Neoplasia
Disease Progression
Human Papillomavirus-16
Neoplasm Regression
Papillomavirus E7 Proteins
Viral Oncogene Proteins
Citation: Biomarker Insights. v. 9, p. 15-22, 2014.
Rights: aberto
Identifier DOI: 10.4137/BMI.S14296
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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