Please use this identifier to cite or link to this item:
|Title:||Desorption/ionization efficiencies oftriacylglycerols and phospholipidsvia EASI-MS|
|Author:||Fernandes, Anna Maria A. P.|
Fernandes, Gabriel D.
Sá, Gilberto F. de
Lins, Roberto D.
Eberlin, Marcos N.
Alberici, Rosana M.
|Abstract:||Knowledge of the major effects governing desorption/ionization efficiency is required for the development and application of ambient mass spectrometry. Although all triacylglycerols (TAG) have the same favorable protonation and cationization sites, their desorption/ionization efficiencies can vary dramatically during easy ambient sonic-spray ionization because of structural differences in the carbon chain. To quantify this somewhat surprising and drastic effect, we have performed a systematic investigation of desorption/ionization efficiencies as a function of unsaturation and length for TAG as well as for diacylglycerols, monoacylglycerols and several phospholipids (PL). Affinities for Na(+) as a function of unsaturation level have also been assayed via comprehensive metadynamics calculations to understand the influence of this phenomenon on the ionization efficiency. The results suggest that dipole-dipole interactions within a carbon chain tuned by unsaturation sites govern ionization efficiency of TAG and PL.|
Knowledge of the major effects governing desorption/ionization efficiency is required for the development and application ofambient mass spectrometry. Although all triacylglycerols (TAG) have the same favorable protonation and cationization sites,their de
Simulação de dinâmica molecular
|Editor:||John Wiley & Sons|
|Citation:||Journal Of Mass Spectrometry : Jms. v. 49, n. 5, p. 335-41, 2014-May.|
|Appears in Collections:||IQ - Artigos e Outros Documentos|
FEA - Artigos e Outros Documentos
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.