Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/201340
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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleComparative Study Of Tissue Reactivity To N-butyl-2-cyanoacrylate And Nylon Monofilament Thread On Pericranium-cutaneous Flaps In Rats.pt_BR
dc.contributor.authorCavazana, William Césarpt_BR
dc.contributor.authorIoshii, Sergio Osamupt_BR
dc.contributor.authorNakamura Cuman, Roberto Kenjipt_BR
dc.contributor.authorPasseri, Luis Augustopt_BR
unicamp.authorLuis Augusto Passeri, Department of Surgery, Faculty of Medical Sciences, UNICAMP, Sao Paulo, SP, Brazil.pt_BR
unicamp.author.externalWilliam César Cavazana, Department of Medicine, Center of Health Sciences, State University of Maringa, Maringa, PR, Brazil.pt
unicamp.author.externalSergio Osamu Ioshii, Federal University of Parana, Curitiba, PR, Brazil.pt
unicamp.author.externalRoberto Kenji Nakamura Cuman, Department of Pharmacology and Therapeutics, Center of Health Sciences, UEM, Maringa, PR, Brazil.pt
dc.subjectAnimalspt_BR
dc.subjectCollagenpt_BR
dc.subjectEnbucrilatept_BR
dc.subjectFibroblastspt_BR
dc.subjectMalept_BR
dc.subjectMaterials Testingpt_BR
dc.subjectNylonspt_BR
dc.subjectPostoperative Periodpt_BR
dc.subjectRandom Allocationpt_BR
dc.subjectRats, Wistarpt_BR
dc.subjectReproducibility Of Resultspt_BR
dc.subjectSkullpt_BR
dc.subjectSurgical Flapspt_BR
dc.subjectSuture Anchorspt_BR
dc.subjectSuture Techniquespt_BR
dc.subjectTime Factorspt_BR
dc.subjectTreatment Outcomept_BR
dc.description.abstractTo study the repair of pericranium-cutaneous flaps fixed with suture anchored in a skull bone tunnel or N-butyl-2-cyanoacrylate adhesive in Wistar rats with emphasis on the cellular inflammatory response and the production of types I and III collagen. The operated region in the cephalic region of Wistar rats was removed minutes before euthanasia, fixed in formalin, and subjected to histological preparation. Slides were stained with hematoxylin-eosin and Picrosirius. Standardized counts of polymorphonuclear and mononuclear cells, fibroblasts, and macrophages were performed, and the percentages of types I and III collagen were determined. Data collection occurred on days 3, 7, 14, 21, and 45 postoperatively. A value of p<0.05 was considered statistically significant. Quantitative analysis of the data showed more fibroblasts in the surgical adhesive group than in the nylon monofilament thread groups (p=0.0211). Qualitative analysis showed higher reactivity in the adhesive group, with a predominance of polymorphonuclear cells from days 3-45 and macrophages from days 3-7. The amount of type I collagen exceeded 80% in the treated and control groups at the end of the experiment. Subperiosteal detachment triggers a cellular inflammatory response that is amplified using soft tissue fixation methods. The adhesive n-butyl-2-cyanoacrylate was more reactive than the nylon monofilament thread anchored in the skull bone tunnel.en
dc.relation.ispartofActa Cirúrgica Brasileira / Sociedade Brasileira Para Desenvolvimento Pesquisa Em Cirurgiapt_BR
dc.relation.ispartofabbreviationActa Cir Braspt_BR
dc.date.issued2014-Aprpt_BR
dc.identifier.citationActa Cirúrgica Brasileira / Sociedade Brasileira Para Desenvolvimento Pesquisa Em Cirurgia. v. 29, n. 4, p. 261-7, 2014-Apr.pt_BR
dc.language.isoengpt_BR
dc.description.volume29pt_BR
dc.description.firstpage261-7pt_BR
dc.rightsabertopt_BR
dc.rights.holderpt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1678-2674pt_BR
dc.identifier.doipt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/24760027pt_BR
dc.date.available2015-11-27T13:42:23Z-
dc.date.accessioned2015-11-27T13:42:23Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:42:23Z (GMT). No. of bitstreams: 1 pmed_24760027.pdf: 1256389 bytes, checksum: b113320dd99b925a95362e0cf1286f8b (MD5) Previous issue date: 2014en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201340-
dc.identifier.idPubmed24760027pt_BR
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