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Type: Artigo de periódico
Title: Novel R-(+)-limonene-based Thiosemicarbazones And Their Antitumor Activity Against Human Tumor Cell Lines.
Author: Vandresen, Fábio
Falzirolli, Hugo
Almeida Batista, Sabrina A
da Silva-Giardini, Ana Paula B
de Oliveira, Diogo N
Catharino, Rodrigo R
Ruiz, Ana Lúcia T G
de Carvalho, João E
Foglio, Mary Ann
da Silva, Cleuza Conceição
Abstract: In an attempt to develop potent and selective antitumor agents, a series of novel thiosemicarbazones derived from a natural monoterpene R-(+)-limonene was synthesized and their antitumor activity was evaluated. Overall, the majority of tested compounds exhibited considerable inhibitory effects on the growth of a wide range of cancer cell lines. Almost all of tested thiosemicarbazones were especially sensitive to prostate cells (PC-3). Derivatives 5, 6, 8, 9, 10, 11 and 13 presented the most potent antitumor activity against PC-3 cells. These compounds showed lower value of GI50 (0.04-0.05 μM) than the reference drug paclitaxel, besides a high selectivity for the same cell line. The 4-fluorobenzaldehyde derivative 10 was the most selective compound for prostate cells, while 2-hydroxybenzaldehyde derivative 8 was the most active compound, with potent antitumor activity against all tested cell lines.
Subject: Antineoplastic Agents
Cell Line, Tumor
Cell Proliferation
Dose-response Relationship, Drug
Drug Screening Assays, Antitumor
K562 Cells
Mcf-7 Cells
Molecular Structure
Structure-activity Relationship
Prostate Cancer Cells
Citation: European Journal Of Medicinal Chemistry. v. 79, p. 110-6, 2014-May.
Rights: fechado
Identifier DOI: 10.1016/j.ejmech.2014.03.086
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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