Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/201311
Type: Artigo de periódico
Title: Novel R-(+)-limonene-based Thiosemicarbazones And Their Antitumor Activity Against Human Tumor Cell Lines.
Author: Vandresen, Fábio
Falzirolli, Hugo
Almeida Batista, Sabrina A
da Silva-Giardini, Ana Paula B
de Oliveira, Diogo N
Catharino, Rodrigo R
Ruiz, Ana Lúcia T G
de Carvalho, João E
Foglio, Mary Ann
da Silva, Cleuza Conceição
Abstract: In an attempt to develop potent and selective antitumor agents, a series of novel thiosemicarbazones derived from a natural monoterpene R-(+)-limonene was synthesized and their antitumor activity was evaluated. Overall, the majority of tested compounds exhibited considerable inhibitory effects on the growth of a wide range of cancer cell lines. Almost all of tested thiosemicarbazones were especially sensitive to prostate cells (PC-3). Derivatives 5, 6, 8, 9, 10, 11 and 13 presented the most potent antitumor activity against PC-3 cells. These compounds showed lower value of GI50 (0.04-0.05 μM) than the reference drug paclitaxel, besides a high selectivity for the same cell line. The 4-fluorobenzaldehyde derivative 10 was the most selective compound for prostate cells, while 2-hydroxybenzaldehyde derivative 8 was the most active compound, with potent antitumor activity against all tested cell lines.
Subject: Antineoplastic Agents
Cell Line, Tumor
Cell Proliferation
Cyclohexenes
Dose-response Relationship, Drug
Drug Screening Assays, Antitumor
Humans
K562 Cells
Mcf-7 Cells
Molecular Structure
Stereoisomerism
Structure-activity Relationship
Terpenes
Thiosemicarbazones
Antitumor
Prostate Cancer Cells
R-(+)-limonene
Thiosemicarbazide
Thiosemicarbazones
Rights: fechado
Identifier DOI: 10.1016/j.ejmech.2014.03.086
Address: http://www.ncbi.nlm.nih.gov/pubmed/24727464
Date Issue: 2014
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

Files in This Item:
File SizeFormat 
pmed_24727464.pdf389.99 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.