Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/201307
Type: Artigo de periódico
Title: Ankhd1, A Novel Component Of The Hippo Signaling Pathway, Promotes Yap1 Activation And Cell Cycle Progression In Prostate Cancer Cells.
Author: Machado-Neto, João Agostinho
Lazarini, Mariana
Favaro, Patricia
Franchi, Gilberto Carlos
Nowill, Alexandre Eduardo
Saad, Sara Teresinha Olalla
Traina, Fabiola
Abstract: ANKHD1 is a multiple ankyrin repeat containing protein, recently identified as a novel member of the Hippo signaling pathway. The present study aimed to investigate the role of ANKHD1 in DU145 and LNCaP prostate cancer cells. ANKHD1 and YAP1 were found to be highly expressed in prostate cancer cells, and ANKHD1 silencing decreased cell growth, delayed cell cycle progression at the S phase, and reduced tumor xenograft growth. Moreover, ANKHD1 knockdown downregulated YAP1 expression and activation, and reduced the expression of CCNA2, a YAP1 target gene. These findings indicate that ANKHD1 is a positive regulator of YAP1 and promotes cell growth and cell cycle progression through Cyclin A upregulation.
Subject: Adaptor Proteins, Signal Transducing
Animals
Cell Cycle
Cell Line, Tumor
Cyclin A
Gene Expression Regulation, Neoplastic
Hela Cells
Humans
K562 Cells
Male
Mice
Mice, Inbred Nod
Mice, Scid
Mice, Transgenic
Phosphoproteins
Prostatic Neoplasms
Protein-serine-threonine Kinases
Rna-binding Proteins
Signal Transduction
Transcriptional Activation
Ankhd1
Cell Cycle
Hippo Pathway
Mask
Prostate Cancer
Yap1
Rights: fechado
Identifier DOI: 10.1016/j.yexcr.2014.04.004
Address: http://www.ncbi.nlm.nih.gov/pubmed/24726915
Date Issue: 2014
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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