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Type: Artigo de periódico
Title: Maximal Testosterone Suppression In Prostate Cancer--free Vs Total Testosterone.
Author: Rove, Kyle O
Crawford, E David
Perachino, Massimo
Morote, Juan
Klotz, Laurence
Lange, Paul H
Andriole, Gerald L
Matsumoto, Alvin M
Taneja, Samir S
Eisenberger, Mario A
Reis, Leonardo O
Abstract: Testosterone remains a key target in the treatment of advanced prostate cancer. The relationship of free testosterone to prostate cancer treatment and outcomes remains largely unexplored. A consensus of prostate cancer experts was convened in 2013 to review current knowledge surrounding relationship of total and free testosterone to prostate cancer, discuss the free hormone hypothesis, and highlight future avenues for therapeutics. Free testosterone may better reflect prostate cancer tissue androgen levels than serum total testosterone concentration. Free testosterone deserves more research regarding its relation to clinical outcomes.
Subject: Aged
Androgen Antagonists
Follow-up Studies
Middle Aged
Neoplasms, Hormone-dependent
Prostate-specific Antigen
Prostatic Neoplasms
Risk Assessment
Survival Analysis
Treatment Outcome
Tumor Markers, Biological
Citation: Urology. v. 83, n. 6, p. 1217-22, 2014-Jun.
Rights: fechado
Identifier DOI: 10.1016/j.urology.2014.02.001
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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