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Type: Artigo de periódico
Title: Fluorescence Spectroscopy For The Detection Of Potentially Malignant Disorders And Squamous Cell Carcinoma Of The Oral Cavity.
Author: Francisco, Ana Lucia Noronha
Correr, Wagner Rafael
Azevedo, Luciane Hiramatsu
Kern, Vivian Galletta
Pinto, Clóvis Antônio Lopes
Kowalski, Luiz Paulo
Kurachi, Cristina
Abstract: Oral cancer is a public health problem with relevant incidence in the world population. The affected patient usually presents advanced stage disease and the consequence of this delay is a reduction in survival rates. Given this, it is essential to detect oral cancer at early stages. Fluorescence spectroscopy is a non-invasive diagnostic tool that can improve cancer detection in real time. It is a fast and accurate technique, relatively simple, which evaluates the biochemical composition and structure using the tissue fluorescence spectrum as interrogation data. Several studies have positive data regarding the tools for differentiating between normal mucosa and cancer, but the difference between cancer and potentially malignant disorders is not clear. The aim of this study was to evaluate the efficacy of fluorescence spectroscopy in the discrimination of normal oral mucosa, oral cancer, and potentially malignant disorders. The fluorescence spectroscopy was evaluated in 115 individuals, of whom 55 patients presented oral squamous cell carcinoma, 30 volunteers showing normal oral mucosa, and 30 patients having potentially malignant disorders. The spectra were classified and compared to histopathology to evaluate the efficiency in diagnostic discrimination employing fluorescence. In order to classify the spectra, a decision tree algorithm (C4.5) was applied. Despite of the high variance observed in spectral data, the specificity and sensitivity obtained were 93.8% and 88.5%, respectively at 406 nm excitation. These results point to the potential use of fluorescence spectroscopy as an important tool for oral cancer diagnosis and potentially malignant disorders.
Subject: Algorithms
Carcinoma, Squamous Cell
Diagnosis, Computer-assisted
Head And Neck Neoplasms
Middle Aged
Mouth Mucosa
Mouth Neoplasms
Reproducibility Of Results
Sensitivity And Specificity
Spectrometry, Fluorescence
Tumor Markers, Biological
Early Diagnosis
Fluorescence Spectroscopy
Oral Cavity
Potentially Malignant Disorders
Squamous Cell Carcinoma
Citation: Photodiagnosis And Photodynamic Therapy. v. 11, n. 2, p. 82-90, 2014-Jun.
Rights: fechado
Identifier DOI: 10.1016/j.pdpdt.2014.03.009
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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