Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/201255
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampSerpe, Lucianopt_BR
dc.contributor.authorunicampFranz-Montan, Michellept_BR
dc.contributor.authorunicampSantos, Cleiton Pita dospt_BR
dc.contributor.authorunicampSilva, Camila Batista dapt_BR
dc.contributor.authorunicampNolasco, Fabiana Pinchettipt_BR
dc.contributor.authorunicampCaldas, Cristina Saragiottopt_BR
dc.contributor.authorunicampVolpato, Maria Cristinapt_BR
dc.contributor.authorunicampPaula, Eneida dept_BR
dc.contributor.authorunicampGroppo, Francisco Carlospt_BR
dc.typeArtigopt_BR
dc.titleAnaesthetic efficacy of bupivacaine 2-hydroxypropyl-β-cyclodextrin for dental anaesthesia after inferior alveolar nerve block in rats.pt_BR
dc.contributor.authorSerpe, L.pt_BR
dc.contributor.authorFranz-Montan, M.pt_BR
dc.contributor.authorSantos, C. P. dospt_BR
dc.contributor.authorSilva, C. B. dapt_BR
dc.contributor.authorNolasco, F. P.pt_BR
dc.contributor.authorCaldas, C. S.pt_BR
dc.contributor.authorVolpato, M. C.pt_BR
dc.contributor.authorPaula, E. dept_BR
dc.contributor.authorGroppo, F. C.pt_BR
dc.subjectCiclodextrinaspt_BR
dc.subjectBupivacaínapt_BR
dc.subjectAnestésicos locaispt_BR
dc.subject.otherlanguageCyclodextrinspt_BR
dc.subject.otherlanguageBupivacainept_BR
dc.subject.otherlanguageLocal anestheticspt_BR
dc.description.abstractBupivacaine is a long-acting local anaesthetic that is widely used in medicine and dentistry. The duration and intensity of its sensory blockade in animal models is increased by its inclusion in complexes with cyclodextrins. The aim of the present study was to evaluate the anaesthetic efficacy of bupivacaine 2-hydroxypropyl-β-cyclodextrin (HPβCD) inclusion complex for dental anaesthesia after inferior alveolar nerve block in rats. Thirty rats were each given an injection close to the mandibular foramen of 0.2ml of one of the following formulations: 0.5% bupivacaine alone; 0.5% bupivacaine with 1:200,000 epinephrine; and 0.5% bupivacaine-HPβCD inclusion complex (bupivacaine-HPβCD). The other sides were used as controls, with either 0.9% saline or anaesthetic-free HPβCD solution being injected. The onset, success, and duration of pulpal anaesthesia were assessed by electrical stimulation (pulp tester) on inferior molars. Results were analysed using ANOVA (Tukey), log rank, and chi square tests (α=5%). There were no differences among the formulations in onset of anaesthesia (p=0.59) or between the bupivacaine plus epinephrine and bupivacaine plus HPβCD in duration of anaesthesia, but bupivacaine plus epinephrine gave significantly higher values than bupivacaine alone (p=0.007). Bupivacaine plus epinephrine was a better anaesthetic than bupivacaine alone (p=0.02), while Bupi-HPβCD gave intermediate results, and therefore did not differ significantly from the other 2 groups (p=0.18 with bupivacaine alone; and p=0.44 with bupivacaine plus epinephrine). The bupivacaine-HPβCD complex showed similar anaesthetic properties to those of bupivacaine with epinephrine.en
dc.description.abstractBupivacaine is a long-acting local anaesthetic that is widely used in medicine and dentistry. The duration and intensity of its sensory blockade in animal models is increased by its inclusion in complexes with cyclodextrins. The aim of the present study was to evaluate the anaestheticefficacy of bupivacaine 2-hydroxypropyl-β-cyclodextrin (HPβCD) inclusion complex for dental anaesthesia after inferior alveolar nerve block in rats. Thirty rats were each given an injection close to the mandibular foramen of 0.2ml of one of the following formulations: 0.5% bupivacainealone; 0.5% bupivacaine with 1:200,000 epinephrine; and 0.5% bupivacaine-HPβCD inclusion complex (bupivacaine-HPβCD). The other sides were used as controls, with either 0.9% saline or anaesthetic-free HPβCD solution being injected. The onset, success, and duration of pulpal anaesthesia were assessed by electrical stimulation ("pulp tester") on inferior molars. Results were analysed using ANOVA (Tukey), log rank, and chi square tests (α=5%). There were no differences among the formulations in onset of anaesthesia (p=0.59) or between the bupivacaine plus epinephrine and bupivacaine plus HPβCD in duration of anaesthesia, but bupivacaine plus epinephrine gave significantly higher values than bupivacaine alone (p=0.007). Bupivacaine plus epinephrine was a better anaesthetic than bupivacaine alone (p=0.02), while Bupi-HPβCD gave intermediate results, and therefore did not differ significantly from the other 2 groups (p=0.18 with bupivacaine alone; and p=0.44 with bupivacaine plus epinephrine). The bupivacaine-HPβCD complex showed similar anaesthetic properties to those of bupivacaine with epinephrinept
dc.relation.ispartofBritish journal of oral and maxillofacial surgerypt_BR
dc.relation.ispartofabbreviationBr. j. ora.l maxillofac. surg.pt_BR
dc.publisher.cityOxfordpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherElsevierpt_BR
dc.date.issued2014pt_BR
dc.date.monthofcirculationMaypt_BR
dc.identifier.citationThe British Journal Of Oral & Maxillofacial Surgery. v. 52, n. 5, p. 452-7, 2014-May.pt_BR
dc.language.isoengpt_BR
dc.description.volume52pt_BR
dc.description.issuenumber5pt_BR
dc.description.firstpage452pt_BR
dc.description.lastpage457pt_BR
dc.rightsfechadopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn0266-4356pt_BR
dc.identifier.eissn1532-1940pt_BR
dc.identifier.doi10.1016/j.bjoms.2014.02.018pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0266435614000783pt_BR
dc.description.sponsorshipFAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOpt_BR
dc.description.sponsorship1FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOpt_BR
dc.description.sponsordocumentnumber2006/00121-9; 2009/11820-3pt_BR
dc.date.available2015-11-27T13:42:11Z-
dc.date.accessioned2015-11-27T13:42:11Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:42:11Z (GMT). No. of bitstreams: 1 pmed_24673836.pdf: 240648 bytes, checksum: d69e8f66919d3339f2ce9029ccba73c9 (MD5) Previous issue date: 2014 Bitstreams deleted on 2020-05-14T20:38:51Z: pmed_24673836.pdf,. Added 1 bitstream(s) on 2020-05-14T20:43:12Z : No. of bitstreams: 1 24673836.pdf: 477369 bytes, checksum: 6e1f69241b93378b0f57b541805fd050 (MD5) Bitstreams deleted on 2020-06-04T12:48:04Z: 24673836.pdf,. Added 1 bitstream(s) on 2020-06-04T12:53:14Z : No. of bitstreams: 1 24673836.pdf: 728983 bytes, checksum: bd513772d7294a68efb02124f2d34a6b (MD5)en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201255-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Ciências Fisiológicaspt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Ciências Fisiológicaspt_BR
dc.contributor.departmentDepartamento de Bioquímica e Biologia Tecidualpt_BR
dc.contributor.departmentDepartamento de Ciências Fisiológicaspt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.subject.keywordInferior alveolar nerve blockpt_BR
dc.subject.keywordLocal anaesthesiapt_BR
dc.identifier.source24673836-
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0003-0760-1389pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0002-1459-7050pt_BR
dc.creator.orcid0000-0003-4504-5723pt_BR
dc.creator.orcid0000-0002-8513-773Xpt_BR
dc.type.formArtigopt_BR
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