Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/201226
Type: Artigo de periódico
Title: Analysis Of Surgical Margins In Oral Cancer Using In Situ Fluorescence Spectroscopy.
Author: Francisco, Ana Lucia Noronha
Correr, Wagner Rafael
Pinto, Clóvis Antônio Lopes
Gonçalves Filho, João
Chulam, Thiago Celestino
Kurachi, Cristina
Kowalski, Luiz Paulo
Abstract: Oral cancer is a public health problem with high prevalence in the population. Local tumor control is best achieved by complete surgical resection with adequate margins. A disease-free surgical margin correlates with a lower rate of local recurrence and a higher rate of disease-free survival. Fluorescence spectroscopy is a noninvasive diagnostic tool that can aid in real-time cancer detection. The technique, which evaluates the biochemical composition and structure of tissue fluorescence, is relatively simple, fast and, accurate. This study aimed to compare oral squamous cell carcinoma lesions to surgical margins and the mucosa of healthy volunteers by fluorescence spectroscopy. The sample consisted of 56 individuals, 28 with oral squamous cell carcinoma and 28 healthy volunteers with normal oral mucosa. Thirty six cases (64.3%) were male and the mean age was 60.9 years old. The spectra were classified and compared to histopathology to determine fluorescence efficiency for diagnostic discrimination of tumors. In the analysis of the other cases we observed discrimination between normal mucosa, injury and margins. At two-year follow up, three individuals had local recurrence, and in two cases investigation fluorescence in the corresponding area showed qualitative differences in spectra between the recurrence area and the area without recurrence at the same anatomical site in the same patient. In situ analysis of oral mucosa showed the potential of fluorescence spectroscopy as a diagnostic tool that can aid in discrimination of altered mucosa and normal mucosa.
Subject: Adult
Aged
Aged, 80 And Over
Alcohol Drinking
Case-control Studies
Female
Humans
Male
Middle Aged
Mouth Neoplasms
Smoking
Spectrometry, Fluorescence
Diagnosis
Fluorescence Spectroscopy
Oral Cavity
Squamous Cell Carcinoma
Surgical Margins
Rights: fechado
Identifier DOI: 10.1016/j.oraloncology.2014.02.008
Address: http://www.ncbi.nlm.nih.gov/pubmed/24630901
Date Issue: 2014
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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