Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/201223
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampFigueroba Raimundo, Sidneypt_BR
dc.contributor.authorunicampDesjardins, Marina Passarellapt_BR
dc.contributor.authorunicampNani, Bruno Diaspt_BR
dc.contributor.authorunicampFerreira, Luiz Eduardo Nunespt_BR
dc.contributor.authorunicampRossi, Ana Cláudiapt_BR
dc.contributor.authorunicampVenâncio, Paulo Césarpt_BR
dc.contributor.authorunicampAguiar, Flávio Henrique Baggiopt_BR
dc.contributor.authorunicampGroppo, Francisco Carlospt_BR
dc.typeArtigopt_BR
dc.titleEffect of diazepam on temporomandibular joints in rats with increased occlusal vertical dimension.pt_BR
dc.contributor.authorFigueroba, S. R.pt_BR
dc.contributor.authorDesjardins, M. P.pt_BR
dc.contributor.authorNani, B. D.pt_BR
dc.contributor.authorFerreira, L. E. N.pt_BR
dc.contributor.authorRossi, A. C.pt_BR
dc.contributor.authorSantos, F. A.pt_BR
dc.contributor.authorVenâncio, P. C.pt_BR
dc.contributor.authorAguiar, F. H. B.pt_BR
dc.contributor.authorGroppo, F. C.pt_BR
dc.subjectDiazepampt_BR
dc.subjectArticulação temporomandibular- Doençaspt_BR
dc.subjectRatopt_BR
dc.subjectCitocinaspt_BR
dc.subject.otherlanguageDiazepampt_BR
dc.subject.otherlanguage Temporomandibular joint-Diseasept_BR
dc.subject.otherlanguage Ratspt_BR
dc.subject.otherlanguage Cytokinespt_BR
dc.description.abstractAnxiolytic agents, mainly benzodiazepines, have been used to treat symptomatic disorders of the temporomandibular joint (TMJ). Our aim was to evaluate the effect of diazepam on the TMJ of rats with increased occlusal vertical dimension (iOVD). Forty male rats were randomly assigned to 4 groups: control rats were given sham iOVD plus saline solution daily for 7 days. The first experimental group was given sham iOVD plus diazepam 2.5mg/kg/intramuscularly daily for 7 days (diazepam alone group); the second had iOVD induced in molars for 7 days plus saline daily for 7 days (iOVD alone group); and the third had iOVD induced in molars for 7 days plus diazepam 2.5mg/kg/intramuscularly daily for 7 days (iOVD plus diazepam group). At the end of each experiment the animals were killed and their bilateral TMJs were removed, randomly stained with haematoxylin and eosin and sirius-red, and immunoassayed. The thickness of condylar cartilage and of fibrous, proliferating, mature, and hypertrophic layers, number of collagen fibres, and the articular area were measured. Proinflammatory cytokines (interleukin (IL)-1α, IL-1β, IL-6, and tumour necrosis factor (TNF)-α) were also measured. ANOVA and Tukey's tests or the Kruskal-Wallis test were used to compare data among groups (α=5%). Condylar cartilage was thicker in the control group than in the other groups, the diazepam alone group being thicker than the other 2 experimental groups. There were fewer collagen fibres in the 2 groups given diazepam than in the other 2 groups, and there were no significant differences in the area of cartilage among groups. The controls had lower concentrations of all cytokines (p<0.05) than the 3 experimental groups, except for IL-6. Both iOVD groups had higher concentrations of IL-1α, IL-1β, and IL-6 than the diazepam alone group. Diazepam alone was associated with increased concentrations of all cytokines except IL-6. We conclude that both iOVD and diazepam induced significant changes in rats' articular cartilage.en
dc.description.abstractAnxiolytic agents, mainly benzodiazepines, have been used to treat symptomatic disorders of the temporomandibular joint (TMJ). Our aim was to evaluate the effect of diazepam on the TMJ of rats with increased occlusal vertical dimension (iOVD). Forty male rats were randomly assigned to 4 groups: control rats were given sham iOVD plus saline solution daily for 7 days. The first experimental group was given sham iOVD plus diazepam 2.5 mg/kg/intramuscularly daily for 7 days (diazepam alone group); the second had iOVD induced in molars for 7 days plus saline daily for 7 days (iOVD alone group); and the third had iOVD induced in molars for 7 days plus diazepam 2.5 mg/kg/intramuscularly daily for 7 days (iOVD plus diazepam group). At the end of each experiment the animals were killed and their bilateral TMJs were removed, randomly stained with haematoxylin and eosin and sirius-red, and immunoassayed. The thickness of condylar cartilage and of fibrous, proliferating, mature, and hypertrophic layers, number of collagen fibres, and the articular area were measured. Proinflammatory cytokines (interleukin (IL)-1α, IL-1β, IL-6, and tumour necrosis factor (TNF)-α) were also measured. ANOVA and Tukey's tests or the Kruskal–Wallis test were used to compare data among groups (α = 5%). Condylar cartilage was thicker in the control group than in the other groups, the diazepam alone group being thicker than the other 2 experimental groups. There were fewer collagen fibres in the 2 groups given diazepam than in the other 2 groups, and there were no significant differences in the area of cartilage among groups. The controls had lower concentrations of all cytokines (p < 0.05) than the 3 experimental groups, except for IL-6. Both iOVD groups had higher concentrations of IL-1α, IL-1β, and IL-6 than the diazepam alone group. Diazepam alone was associated with increased concentrations of all cytokines except IL-6. We conclude that both iOVD and diazepam induced significant changes in rats’ articular cartilagept
dc.relation.ispartofBritish journal of oral and maxillofacial surgerypt_BR
dc.relation.ispartofabbreviationBr. j. ora.l maxillofac. surg.pt_BR
dc.publisher.cityOxfordpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherElsevierpt_BR
dc.date.issued2014pt_BR
dc.date.monthofcirculationMaypt_BR
dc.identifier.citationThe British Journal Of Oral & Maxillofacial Surgery. v. 52, n. 5, p. 438-44, 2014-May.pt_BR
dc.language.isoengpt_BR
dc.description.volume52pt_BR
dc.description.issuenumber5pt_BR
dc.description.firstpage438pt_BR
dc.description.lastpage444pt_BR
dc.rightsfechadopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn0266-4356pt_BR
dc.identifier.eissn1532-1940pt_BR
dc.identifier.doi10.1016/j.bjoms.2014.02.009pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0266435614000692pt_BR
dc.description.sponsorshipCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOpt_BR
dc.description.sponsorship1CNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOpt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.date.available2015-11-27T13:42:07Z-
dc.date.accessioned2015-11-27T13:42:07Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:42:07Z (GMT). No. of bitstreams: 1 pmed_24629451.pdf: 1177791 bytes, checksum: d4699ac185623e87637dacd6f4f83a74 (MD5) Previous issue date: 2014 Bitstreams deleted on 2020-05-14T20:38:51Z: pmed_24629451.pdf,. Added 1 bitstream(s) on 2020-05-14T20:43:11Z : No. of bitstreams: 1 24629451.pdf: 476012 bytes, checksum: ba9eb56ec1eedc64551dcfdbed37a0ca (MD5) Bitstreams deleted on 2020-06-04T12:48:03Z: 24629451.pdf,. Added 1 bitstream(s) on 2020-06-04T12:53:14Z : No. of bitstreams: 1 24629451.pdf: 1663082 bytes, checksum: 6f281be9e4d3247379dc036055831608 (MD5)en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201223-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Morfologiapt_BR
dc.contributor.departmentDepartamento de Exataspt_BR
dc.contributor.departmentDepartamento de Odontologia Restauradorapt_BR
dc.contributor.departmentDepartamento de Ciências Fisiológicaspt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeColégio Técnico de Limeirapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.subject.keywordRat modelpt_BR
dc.identifier.source24629451-
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0002-8718-4898pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0003-3389-5536pt_BR
dc.creator.orcid0000-0002-8513-773Xpt_BR
dc.type.formArtigopt_BR
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