Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/201210
Type: Artigo
Title: Taurine-induced insulin signalling improvement of obese malnourished mice is associated with redox balance and protein phosphatases activity modulation
Author: Cappelli, Ana P.
Zoppi, Claudio C.
Barbosa-Sampaio, Helena C.
Costa-Jr, José M.
Protzek, André O.
Morato, Priscila N.
Boschero, Antonio C.
Carneiro, Everardo M.
Abstract: Obese protein malnourished mice display liver insulin resistance and taurine (TAU) seems to attenuate this effect. The association between early-life malnutrition and hepatic redox balance in diet-induced insulin resistance is unknown. We investigated TAU supplementation effects upon liver redox state and insulin signalling in obese protein malnourished mice. Weaned male C57BL-6 mice were fed a control (14% protein - C) or a protein-restricted diet (6% protein - R) for 6 weeks. Afterwards, mice received a high-fat diet (34% fat - HFD) for 8 weeks (CH - RH). Half of the HFD-mice were supplemented with TAU (5%) throughout the treatment (CHT - RHT). Body and tissues' weight, respiratory quotient (RQ), glucose tolerance and insulin sensitivity, hepatic oxidant and antioxidant markers and insulin cascade proteins were assessed. Protein restriction leads to typical features whereas HFD was able to induce a catch-up growth in RH. HFD-groups showed higher energy intake and adiposity, lower energy expenditure and altered RQ. Glucose tolerance and insulin sensitivity were impaired in HFD-groups and TAU attenuated these effects. H2 O2 content was increased in CHT and RHT despite no differences in antioxidant enzymes and GSH concentration. AKT and PTEN phosphorylation were significantly increased in CHT but not in RHT. Our data provide evidence for an association between TAU-induced improved glycaemic control because of PTEN inactivation and higher AKT phosphorylation. These effects seem to be related with altered hepatic redox balance in obese mice, and this effect is impaired by protein malnutrition.
Obese protein malnourished mice display liver insulin resistance and taurine (TAU) seems to attenuate this effect. The association between early‐life malnutrition and hepatic redox balance in diet‐induced insulin resistance is unknown. We investigated TAU
Subject: Enzimas antioxidantes
Peróxido de hidrogênio
Fígado
PTEN Fosfo-hidrolase
Proteína tirosina fosfatase não receptora tipo 1
Country: Reino Unido
Editor: Wiley
Citation: Liver International : Official Journal Of The International Association For The Study Of The Liver. v. 34, n. 5, p. 771-83, 2014-May.
Rights: fechado
fechado
Identifier DOI: 10.1111/liv.12291
Address: https://onlinelibrary.wiley.com/doi/full/10.1111/liv.12291
Date Issue: 2014
Appears in Collections:IB - Artigos e Outros Documentos
FEA - Artigos e Outros Documentos

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