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Type: Artigo de periódico
Title: Human Vaginal Histology In Long-term Users Of The Injectable Contraceptive Depot-medroxyprogesterone Acetate.
Author: Bahamondes, M Valeria
Castro, Sara
Marchi, Nadia M
Marcovici, Michele
Andrade, Liliana A L A
Fernandes, Arlete
Bahamondes, Luis
Abstract: Apparently, depot-medroxyprogesterone acetate (DMPA) increases a woman's risk of acquiring HIV. The objective of this study was to test whether the vaginal mucosal thickness and Langerhans cell counts were significantly different in long-term DMPA users compared with women users of an intrauterine device (IUD) who had never used DMPA. Cross-sectional study. Twenty-three DMPA users were matched with 23 nonusers controlled for age, body mass index (BMI; kg/m²), and duration of contraceptive use. Four groups of women were evaluated according to the duration of DMPA use: >1, <5; ≥5, <10; ≥10, <15 or ≥15 years. Estradiol (E₂) levels were compared between the two groups. Histologic sections of vaginal mucosal biopsies were evaluated to measure the mean epithelial thickness and S100 immunostained sections were used to count the number of Langerhans cells/mm. Mean (±S.D.) E₂ levels were significantly lower in DMPA users (39.4±26.6 pg/mL) compared with nonusers (102.6±60.3 pg/mL) despite similar ages (42.3±7.4 and 42.4±7.4 years, respectively). Mean (±S.D.) vaginal thickness was 232.6±108.1 and 229.7±112.9 in DMPA users and nonusers, respectively. There were no differences in vaginal thickness or Langerhans cell count/mm between users and nonusers even after controlling for DMPA duration of use. Vaginal epithelial thinning or Langerhans cell count was not different between long-term DMPA users and copper-IUD users who had never used DMPA. No differences were found in vaginal epithelial thickness or in Langerhans cell count between long-term users of the injectable contraceptive DMPA and nonusers.
Subject: Adult
Cell Count
Contraceptive Agents, Female
Cross-sectional Studies
Delayed-action Preparations
Hospitals, University
Intrauterine Devices
Langerhans Cells
Medroxyprogesterone Acetate
Middle Aged
Mucous Membrane
Organ Size
Outpatient Clinics, Hospital
Reproducibility Of Results
Time Factors
Injectable Contraceptive
Long-term Users
Reproductive Age
Vaginal Histology
Rights: fechado
Identifier DOI: 10.1016/j.contraception.2014.01.024
Date Issue: 2014
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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