Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/201175
Type: Artigo
Title: Clinicopathological prognostic factors of oral tongue squamous cell carcinoma: a retrospective study of 202 cases
Author: Rodrigues, P. C.
Miguel, M. C. C.
Bagordakis, E.
Fonseca, F. P.
de Aquino, S. N.
Santos-Silva, A. R.
Lopes, M. A.
Graner, E.
Salo, T.
Kowalski, L. P.
Coletta, R. D.
Abstract: Although several histopathological parameters and grading systems have been described as predictive of the treatment response and outcome of oral squamous cell carcinoma (OSCC), none is universally accepted. A new scoring system, the histological risk model, was recently described to be a powerful predictive tool for recurrence and overall survival in OSCC. The aim of this study was to verify the predictive role of the histological risk model in a cohort of 202 patients at all stages of oral/mobile tongue squamous cell carcinoma (OTSCC). Demographic and clinical data were collected from the medical records and the tumours were evaluated using the histological risk model. Statistical analyses were performed using the χ(2) test, the Kaplan-Meier method, and the Cox regression model. The histological risk model showed no statistical correlation with demographic or clinical parameters and did not Predict the outcome of the OTSCC patients. However, multivariate regression analysis revealed a significant correlation of the clinical disease stage with the disease outcome. Despite major efforts to identify new predictive parameters and histological systems, clinical features are still the most reliable prognostic factors for patients with OTSCC.
Although several histopathological parameters and grading systems have been described as predictive of the treatment response and outcome of oral squamous cell carcinoma (OSCC), none is universally accepted. A new scoring system, the histological risk model, was recently described to be a powerful predictive tool for recurrence and overall survival in OSCC. The aim of this study was to verify the predictive role of the histological risk model in a cohort of 202 patients at all stages of oral/mobile tongue squamous cell carcinoma (OTSCC). Demographic and clinical data were collected from the medical records and the tumours were evaluated using the histological risk model. Statistical analyses were performed using the χ(2) test, the Kaplan-Meier method, and the Cox regression model. The histological risk model showed no statistical correlation with demographic or clinical parameters and did not Predict the outcome of the OTSCC patients. However, multivariate regression analysis revealed a significant correlation of the clinical disease stage with the disease outcome. Despite major efforts to identify new predictive parameters and histological systems, clinical features are still the most reliable prognostic factors for patients with OTSCC
Subject: Carcinoma de células escamosas
Prognóstico
Country: Reino Unido
Editor: Elsevier
Citation: International Journal Of Oral And Maxillofacial Surgery. v. 43, n. 7, p. 795-801, 2014-Jul.
Rights: fechado
Identifier DOI: 10.1016/j.ijom.2014.01.014
Address: https://www.sciencedirect.com/science/article/pii/S0901502714000563
Date Issue: 2014
Appears in Collections:FOP - Artigos e Outros Documentos

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