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Type: Artigo de periódico
Title: Apoliprotein E Genotype Is Associated With Apoliprotein B Plasma Levels But Not With Coronary Calcium Score In Very Elderly Individuals In Primary Care Setting.
Author: Henriques, Adriane D
Tonet-Furioso, Audrey C
Machado-Silva, Wilcelly
Freitas, Wladimir M
Quaglia, Luiz A
Santos, Simone N
Córdova, Cláudio
Sposito, Andrei C
Nóbrega, Otávio T
Abstract: Epidemiological surveys indicate the influence of polymorphisms of apolipoprotein (apo) E on plasma lipids and triglyceride-rich lipoprotein levels, with impact on atherosclerotic phenotypes. We studied the association of classic genotypes of the apoE gene with clinical and biochemical risk factors for atherosclerosis in a segment of the very-old Brazilian individuals, with emphasis on the lipemic profile. We performed cross-sectional analyses of clinical and laboratory assessments, including cardiac computed tomography, across ε2, ε3 and ε4 carriers of the apoE gene with a convenience sample of 208 participants eligible for prevention against cardiovascular events. When non-ε4 carriers were compared with ε4 carrying subjects, lower levels of ApoB as well as ApoB/ApoA ratios were observed in the former group. Tests between apoE polymorphisms with other clinical/biochemical variables and those with arterial calcification showed no significant differences between groups. The study suggests a possible atherogenic role of the ε4 allele attributable to increased ApoB levels and ApoB/ApoA ratios among very-old subjects in primary care setting.
Subject: Age Factors
Aged, 80 And Over
Apolipoproteins E
Biological Markers
Coronary Vessels
Cross-sectional Studies
Follow-up Studies
Gene Frequency
Polymerase Chain Reaction
Primary Health Care
Prospective Studies
Risk Factors
Lipid Metabolism
Primary Prevention
Rights: fechado
Identifier DOI: 10.1016/j.gene.2014.01.077
Date Issue: 2014
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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