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Type: Artigo de periódico
Title: Antiproliferative Activity And Induction Of Apoptosis In Pc-3 Cells By The Chalcone Cardamonin From Campomanesia Adamantium (myrtaceae) In A Bioactivity-guided Study.
Author: Pascoal, Aislan Cristina Rheder Fagundes
Ehrenfried, Carlos Augusto
Lopez, Begoña Gimenez-Cassina
de Araujo, Thiago Matos
Pascoal, Vinicius D'ávila Bitencourt
Gilioli, Rovilson
Anhê, Gabriel Forato
Ruiz, Ana Lúcia Tasca Goes
Carvalho, João Ernesto de
Stefanello, Maria Elida Alves
Salvador, Marcos José
Abstract: The Myrtaceae family is a common source of medicines used in the treatment of numerous diseases in South America. In Brazil, fruits of the Campomanesia species are widely used to make liqueurs, juices and sweets, whereas leaves are traditionally employed as a medicine for dysentery, stomach problems, diarrhea, cystitis and urethritis. Ethanol extracts of Campomanesia adamantium (Myrtaceae) leaves and fruits were evaluated against prostate cancer cells (PC-3). The compound (2E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one, cardamonin) was isolated from ethanol extracts of C. adamantium leaves in a bioactivity-guided study and quantified by UPLC-MS/MS. In vitro studies showed that the isolated chalcone cardamonin inhibited prostate cancer cell proliferation and decreased the expression of NFkB1. Moreover, analysis by flow cytometry showed that this compound induced DNA fragmentation, suggesting an effect on apoptosis induction in the PC-3 cell line.
Subject: Apoptosis
Cell Line, Tumor
Cell Proliferation
Plant Extracts
Prostatic Neoplasms
Rights: aberto
Identifier DOI: 10.3390/molecules19021843
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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