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Type: Artigo de periódico
Title: Further Constituents Of Galianthe Thalictroides (rubiaceae) And Inhibition Of Dna Topoisomerases I And Iiα By Its Cytotoxic β-carboline Alkaloids.
Author: de Oliveira Figueiredo, Patrícia
Perdomo, Renata Trentin
Garcez, Fernanda Rodrigues
de Fatima Cepa Matos, Maria
de Carvalho, João Ernesto
Garcez, Walmir Silva
Abstract: A new cytotoxic β-carboline alkaloid, 1-methyl-3-(2-hydroxypropan-2-yl)-2-(5-methoxy-9H-β-carbolin-1-yl)-cyclopentanol (1), was isolated from roots of Galianthe thalictroides, together with the alkaloid 1-(hydroxymethyl)-3-(2-hydroxypropan-2-yl)-2-(5-methoxy-9H-β-carbolin-1-yl)-cyclopentanol (2), the anthraquinones 1-methyl-alizarin and morindaparvin-A, the coumarin scopoletin, homovanillic alcohol, (-)-epicatechin, and the steroids stigmast-4-en-3-one, 4,22-stigmastadien-3-one, campest-4-en-3-one, stigmast-4-en-3,6-dione, 6-β-hydroxy-stigmast-4-en-3-one, stigmasterol, campesterol, β-sitosterol, and β-sitosterol-3-O-β-D-glucopyranoside. Among the previously known compounds, homovanillic alcohol is a novel finding in Rubiaceae, while 1-methyl-alizarin, morindaparvin-A, scopoletin, stigmast-4-en-3-one, 4,22-stigmastadien-3-one, campest-4-en-3-one, stigmast-4-en-3,6-dione, and 6-β-hydroxy-stigmast-4-en-3-one is reported for the first time in the genus Galianthe. The cytotoxic β-carboline alkaloids 1 and 2 exhibited potent antitopoisomerase I and IIα activities and strong evidence is provided for their action as topoisomerase IIα poisons and redox-independent inhibitors.
Subject: Alkaloids
Antigens, Neoplasm
Cell Line, Tumor
Cell Survival
Dna Topoisomerases, Type I
Dna Topoisomerases, Type Ii
Dna-binding Proteins
Mcf-7 Cells
Plant Roots
Topoisomerase Inhibitors
Galianthe Thalictroides
Srb Assay
β-carboline Alkaloids
Rights: fechado
Identifier DOI: 10.1016/j.bmcl.2014.01.039
Date Issue: 2014
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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