Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/201115
Type: Artigo de periódico
Title: Default Mode, Executive Function, And Language Functional Connectivity Networks Are Compromised In Mild Alzheimer's Disease.
Author: Weiler, Marina
Fukuda, Aya
Massabki, Lilian H P
Lopes, Tatila M
Franco, Alexandre R
Damasceno, Benito P
Cendes, Fernando
Balthazar, Marcio L F
Abstract: Alzheimer's disease (AD) is characterized by mental and cognitive problems, particularly with memory, language, visuospatial skills (VS), and executive functions (EF). Advances in the neuroimaging of AD have highlighted dysfunctions in functional connectivity networks (FCNs), especially in the memory related default mode network (DMN). However, little is known about the integrity and clinical significance of FNCs that process other cognitive functions than memory. We evaluated 22 patients with mild AD and 26 healthy controls through a resting state functional MRI scan. We aimed to identify different FCNs: the DMN, language, EF, and VS. Seed-based functional connectivity was calculated by placing a seed in the DMN (posterior cingulate cortex), language (Broca's and Wernicke's areas), EF (right and left dorsolateral prefrontal cortex), and VS networks (right and left associative visual cortex). We also performed regression analyses between individual connectivity maps for the different FCNs and the scores on cognitive tests. We found areas with significant decreases in functional connectivity in patients with mild AD in the DMN and Wernicke's area compared with controls. Increased connectivity in patients was observed in the EF network. Regarding multiple linear regression analyses, a significant correlation was only observed between the connectivity of the DMN and episodic memory (delayed recall) scores. In conclusion, functional connectivity alterations in mild AD are not restricted to the DMN. Other FCNs related to language and EF may be altered. However, we only found significant correlations between cognition and functional connectivity in the DMN and episodic memory performance.
Subject: Aged
Aged, 80 And Over
Alzheimer Disease
Brain
Brain Mapping
Executive Function
Female
Humans
Image Processing, Computer-assisted
Language
Magnetic Resonance Imaging
Male
Middle Aged
Mild Cognitive Impairment
Neural Pathways
Neuropsychological Tests
Peroxides
Urea
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/24484280
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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