Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/201105
Type: Artigo de periódico
Title: Association Between Genetic Polymorphisms In Apoptosis-related Genes And Risk Of Cutaneous Melanoma In Women And Men.
Author: Oliveira, Cristiane
Lourenço, Gustavo Jacob
Rinck-Junior, José Augusto
Cintra, Maria Letícia
Moraes, Aparecida Machado
Lima, Carmen Silvia Passos
Abstract: The P53 Arg72Pro, MDM2 c.+309T>G, BAX c.-248G>A, and BCL2 c.-717C>A polymorphisms have variable roles in the apoptosis pathways. To clarify the roles of these polymorphisms in the risk for cutaneous melanoma (CM). Genomic DNA of 200 CM patients and 215 controls was analyzed by PCR-RFLP. In women, the frequencies of BAX GG (83.0% vs. 71.0%, P=0.04), BCL2 AA (32.0% vs. 15.0%, P=0.003), P53 ArgArg plus BAX GG (84.9% vs. 63.2%, P=0.01), P53 ArgArg plus BCL2 AA (37.0% vs. 13.1%, P=0.003), BAX GG plus BCL2 AA (70.3% vs. 33.3%, P=0.001), MDM2 GG plus BAX GG plus BCL2 AA (27.3% vs. 3.7%, P=0.03), and P53 ArgArg plus MDM2 GG plus BAX GG plus BCL2 AA (33.3% vs. 5.6%, P=0.04) genotypes were higher in patients than in controls. Female carriers of the respective genotypes were under 1.98 (95% CI: 1.01-3.91), 2.87 (95% CI: 1.43-5.77), 3.48 (95% CI: 1.34-9.04), 4.23 (95% CI: 1.63-10.96), 6.04 (95% CI: 2.10-17.37), 25.61 (95% CI: 1.29-507.24), and 25.69 (95% CI: 1.11-593.59)-fold increased risks for CM than others, respectively. In men, the frequencies of BCL2 CA+AA (83.0% vs. 67.6%, P=0.01) and MDM2 TG+GG plus BCL2 CA+AA (94.2% vs. 68.3%, P=0.003) genotypes were higher in patients than in controls. Male carriers of the respective genotypes were under 2.43 (95% CI: 1.23-4.82) and 9.22 (95% CI: 2.16-39.31)-fold increased CM risks than others, respectively. The data suggest for the first time that P53 Arg72Pro, MDM2 c.+309T>G, BAX c.-248G>A, and BCL2 c.-717C>A polymorphisms, enrolled in apoptosis pathways, constitute distinct determinants of CM in women and men.
Subject: Adult
Aged
Aged, 80 And Over
Case-control Studies
Female
Genes, P53
Genotype
Humans
Male
Melanoma
Middle Aged
Polymorphism, Single Nucleotide
Proto-oncogene Proteins C-mdm2
Risk Assessment
Skin Neoplasms
Ultraviolet Rays
Young Adult
Bcl-2-associated X Protein
Apoptosis
Genetic Polymorphisms
Melanoma
Risk
Rights: fechado
Identifier DOI: 10.1016/j.jdermsci.2013.12.010
Address: http://www.ncbi.nlm.nih.gov/pubmed/24461648
Date Issue: 2014
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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