Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/201096
Type: Artigo de periódico
Title: Understanding The Beneficial Effects Of Doxycycline On The Dystrophic Phenotype Of The Mdx Mouse.
Author: Pereira, Juliano Alves
Matsumura, Cintia Yuri
Minatel, Elaine
Marques, Maria Julia
Santo Neto, Humberto
Abstract: The purpose of this study was to better understand the beneficial effects of doxycycline on the dystrophic muscles of the mdx mouse. Doxycycline (DOX) was administered for 36 days, starting on postnatal day 0, via drinking water. Untreated mdx mice received plain water for the same period and served as a control group. DOX decreased the levels of metalloproteinase-9 and tumor necrosis factor-alpha in the biceps brachii and diaphragm of the mdx mice. It also reduced the total amount of calcium in the muscles studied, concomitant with an increase in the levels of calsequestrin 1. The results show that DOX can affect factors that are important in dystrophic pathogenesis and highlight its potential as a readily accessible therapy in clinical trials for treatment of Duchenne muscular dystrophy.
Subject: Aldehydes
Animals
Anti-bacterial Agents
Calcium
Calcium-binding Proteins
Doxycycline
Gene Expression Regulation
Matrix Metalloproteinase 9
Mice
Mice, Inbred C57bl
Mice, Inbred Mdx
Muscular Dystrophy, Animal
Time Factors
Tumor Necrosis Factor-alpha
Dmd
Tnf-α
Calsequestrin 1
Doxycycline
Mdx
Metalloproteinase-9
Rights: fechado
Identifier DOI: 10.1002/mus.24177
Address: http://www.ncbi.nlm.nih.gov/pubmed/24435758
Date Issue: 2014
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

Files in This Item:
File SizeFormat 
pmed_24435758.pdf178.92 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.