Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/201089
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampAndrade, Bruno Augusto Benevenuto dept_BR
dc.contributor.authorunicampFonseca, Felipe Paivapt_BR
dc.contributor.authorunicampGraner, Edgardpt_BR
dc.contributor.authorunicampAlmeida, Oslei Paes dept_BR
dc.typeArtigopt_BR
dc.titleExpression of prox-1 in oral Kaposi's sarcoma spindle cellspt_BR
dc.contributor.authorBenevenuto de Andrade, Bruno Augustopt_BR
dc.contributor.authorRamírez-Amador, Veliapt_BR
dc.contributor.authorAnaya-Saavedra, Gabrielapt_BR
dc.contributor.authorMartínez-Mata, Guillermopt_BR
dc.contributor.authorFonseca, Felipe P.pt_BR
dc.contributor.authorGraner, Edgardpt_BR
dc.contributor.authorPaes de Almeida, Osleipt_BR
unicamp.authorBruno Augusto Benevenuto de Andrade, Oral Pathology Section, Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.pt_BR
unicamp.author.externalVelia Ramírez-Amador,pt
unicamp.author.externalGabriela Anaya-Saavedra,pt
unicamp.author.externalGuillermo Martínez-Mata,pt
unicamp.author.externalFelipe P Fonseca,pt
unicamp.author.externalEdgard Graner,pt
unicamp.author.externalOslei Paes de Almeida,pt
dc.subjectImuno-histoquímicapt_BR
dc.subjectKaposi, Sarcoma dept_BR
dc.subject.otherlanguageImmunohistochemistrypt_BR
dc.subject.otherlanguageKaposi's sarcomapt_BR
dc.description.abstractThe histogenesis of neoplastic spindle cells of Kaposi's sarcoma is still uncertain, but some studies consider it a lymphatic vessel differentiation. Prox-1 is a nuclear transcription factor that plays a major role during embryonic lymphangiogenesis, and it has been considered a specific and sensitive lymphatic endothelial cell marker. The aim of this study was to determine the expression of Prox-1 in oral Kaposi's sarcoma comparing the results with oral benign vascular tumors including capillary hemangiomas and pyogenic granulomas. Expression of Prox-1 and HHV-8 was evaluated by immunohistochemistry in 30 oral Kaposi's sarcoma, 5 oral capillary hemangiomas, and 10 oral pyogenic granulomas. The labeling index was expressed as the percentage of positive cells for each case studied. Statistical comparison was performed using the Wilcoxon-Mann-Whitney rank sum test. Twenty-eight (93.3%) and 30 oral Kaposi's sarcoma cases were positive for Prox-1 and HHV-8, respectively, while all oral benign vascular tumors were negative for these markers. The number of Prox-1 and HHV-8 oral Kaposi's sarcoma-positive cells increased significantly from patch/plaque to nodular histological stages. The expression of Prox-1 in the neoplastic spindle cells supports the view of a lymphatic differentiation in oral Kaposi's sarcoma. Prox-1 may also be involved in the pathogenesis of oral Kaposi's sarcoma as the number of positive spindle cells increased progressively from patch to nodular stages and could be eventually useful as an additional diagnostic tool for differential diagnosis between oral Kaposi's sarcoma and benign oral vascular lesions.en
dc.description.abstractThe histogenesis of neoplastic spindle cells of Kaposi's sarcoma is still uncertain, but some studies consider it a lymphatic vessel differentiation. Prox-1 is a nuclear transcription factor that plays a major role during embryonic lymphangiogenesis, andpt_BR
dc.relation.ispartofJournal of oral pathology and medicinept_BR
dc.relation.ispartofabbreviationJ. oral pathol. med.pt_BR
dc.publisher.cityChichesterpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherWileypt_BR
dc.date.issued2014pt_BR
dc.date.monthofcirculationfeb.pt_BR
dc.identifier.citationJournal Of Oral Pathology & Medicine : Official Publication Of The International Association Of Oral Pathologists And The American Academy Of Oral Pathology. v. 43, n. 2, p. 132-6, 2014-Feb.pt_BR
dc.language.isoengpt_BR
dc.description.volume43pt_BR
dc.description.issuenumber2pt_BR
dc.description.issuesupplementpt_BR
dc.description.firstpage132pt_BR
dc.description.lastpage136pt_BR
dc.rightsfechadopt_BR
dc.rightsFechadopt_br
dc.rights.holder© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.pt_BR
dc.sourcePUBMEDpt_BR
dc.identifier.issn0904-2512pt_BR
dc.identifier.eissn1600-0714pt_BR
dc.identifier.doi10.1111/jop.12097pt_BR
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1111/jop.12097pt_BR
dc.description.sponsorshipFAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOpt_BR
dc.description.sponsorshipCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOpt_BR
dc.description.sponsordocumentnumber2009/53839-2pt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.date.available2015-11-27T13:41:46Z-
dc.date.accessioned2015-11-27T13:41:46Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:41:46Z (GMT). No. of bitstreams: 0 Previous issue date: 2014. Added 1 bitstream(s) on 2021-01-18T17:38:04Z : No. of bitstreams: 1 23763431.pdf: 673916 bytes, checksum: 8e96e8c1259387dbcd9bc9658397487b (MD5)en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201089-
dc.identifier.idPubmed23763431pt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Diagnóstico Oralpt_BR
dc.contributor.departmentDepartamento de Diagnóstico Oralpt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.identifier.source23763431pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0002-4737-7935pt_BR
dc.creator.orcid0000-0003-2002-8003pt_BR
dc.type.formArtigopt_BR
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