Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/201087
Type: Artigo de periódico
Title: Paucity Of Plasmodium Vivax Mature Schizonts In Peripheral Blood Is Associated With Their Increased Cytoadhesive Potential.
Author: Lopes, Stefanie C P
Albrecht, Letusa
Carvalho, Bruna O
Siqueira, André M
Thomson-Luque, Richard
Nogueira, Paulo A
Fernandez-Becerra, Carmen
Del Portillo, Hernando A
Russell, Bruce M
Rénia, Laurent
Lacerda, Marcus V G
Costa, Fabio T M
Abstract: There is now a growing body of evidence that challenges the current view that Plasmodium vivax-infected erythrocyte (Pv-iE) are unable to sequester. Here we used ex vivo adhesion assays with Pv-iE before and after maturation to demonstrate a higher binding potential of schizonts compared to other asexual stages. These experimental results are correlated with our observations in a panel of 50 vivax malaria patients where schizonts were completely absent in 27 isolates, and few schizonts were observed in the remaining patients. These observations prompt a paradigm shift in P. vivax biology and open avenues to investigate the role of Pv-iE sequestration.
Subject: Antimalarials
Cell Adhesion
Chloroquine
Erythrocytes
Humans
Malaria, Vivax
Parasitemia
Plasmodium Vivax
Primaquine
Schizonts
Statistics, Nonparametric
Plasmodium Vivax
Cytoadhesion
Disproportionality
Malaria
Schizonts
Sequestration
Rights: fechado
Identifier DOI: 10.1093/infdis/jiu018
Address: http://www.ncbi.nlm.nih.gov/pubmed/24415786
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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