Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/201085
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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleAscending Nociceptive Control Contributes To The Antinociceptive Effect Of Acupuncture In A Rat Model Of Acute Pain.pt_BR
dc.contributor.authorTobaldini, Glauciapt_BR
dc.contributor.authorAisengart, Betinapt_BR
dc.contributor.authorLima, Marcelo M Spt_BR
dc.contributor.authorTambeli, Claudia Hpt_BR
dc.contributor.authorFischer, Luanapt_BR
unicamp.authorClaudia H Tambeli, Department of Functional and Structural Biology, Institute of Biology, State University of Campinas - UNICAMP, Campinas, São Paulo, Brazil.pt_BR
unicamp.author.externalGlaucia Tobaldini, Department of Physiology, Division of Biological Sciences, Federal University of Parana, Curitiba, Parana, Brazil.pt
unicamp.author.externalBetina Aisengart, Department of Physiology, Division of Biological Sciences, Federal University of Parana, Curitiba, Parana, Brazil.pt
unicamp.author.externalMarcelo M S Lima, Department of Physiology, Division of Biological Sciences, Federal University of Parana, Curitiba, Parana, Brazil.pt
unicamp.author.externalLuana Fischer, Department of Physiology, Division of Biological Sciences, Federal University of Parana, Curitiba, Parana, Brazil. Electronic address: fischer@ufpr.br.pt
dc.subjectAcupuncture Analgesiapt_BR
dc.subjectAcute Painpt_BR
dc.subjectAfferent Pathwayspt_BR
dc.subjectAnimalspt_BR
dc.subjectDisease Models, Animalpt_BR
dc.subjectMalept_BR
dc.subjectNociceptionpt_BR
dc.subjectNociceptive Painpt_BR
dc.subjectPain Measurementpt_BR
dc.subjectRatspt_BR
dc.subjectRats, Wistarpt_BR
dc.subjectAcupuncturept_BR
dc.subjectAnalgesiapt_BR
dc.subjectAscending Nociceptive Controlpt_BR
dc.subjectNociceptionpt_BR
dc.subjectPainpt_BR
dc.description.abstractAcupuncture-induced analgesia depends on the activation of endogenous pain modulation pathways. In this study, we asked whether ascending nociceptive control (ANC), a form of pain-induced analgesia, contributes to the antinociceptive effect of acupuncture. To answer this question, we tested the ability of procedures that block ANC-induced analgesia, at peripheral, spinal, nucleus accumbens and rostral ventral medulla levels, to block acupuncture-induced analgesia. Acupuncture at ST36 (Zusanli), a widely used acupoint located in the hind limb, induced potent heterosegmental antinociception in the orofacial formalin test. The magnitude of this antinociceptive effect was similar to that induced by an intraplantar injection of capsaicin, a procedure classically used to activate ANC. The antinociceptive effect of acupuncture was blocked by sciatic C-fibers depletion (1% perineural capsaicin), spinal administration of a μ-opioid (Cys2,Tyr3,Orn5,Pen7amide, .2 μg) or of a GABAA (bicuculline, .3 μg) receptor antagonist, intra-nucleus accumbens administration of a μ-opioid receptor antagonist (Cys2,Tyr3,Orn5,Pen7amide, 1 μg), or intrarostral ventral medulla administration of a nicotinic acetylcholine receptor antagonist (mecamylamine, .6 μg). In addition, acupuncture at ST36 and/or upper lip formalin induced c-Fos expression in the nucleus accumbens and in rostral ventral medulla. On the basis of these results, we propose that ANC contributes to the antinociceptive effect of acupuncture. This article presents a novel mechanism of acupuncture analgesia, contributing to the understanding of its scientific basis. Because ANC is a pain modulation pathway activated by peripheral noxious stimulation that ascends to supraspinal regions, it could be the link between acupoint stimulation and the central mechanisms underlying acupuncture analgesia.en
dc.relation.ispartofThe Journal Of Pain : Official Journal Of The American Pain Societypt_BR
dc.relation.ispartofabbreviationJ Painpt_BR
dc.date.issued2014-Aprpt_BR
dc.identifier.citationThe Journal Of Pain : Official Journal Of The American Pain Society. v. 15, n. 4, p. 422-34, 2014-Apr.pt_BR
dc.language.isoengpt_BR
dc.description.volume15pt_BR
dc.description.firstpage422-34pt_BR
dc.rightsfechadopt_BR
dc.rights.holderCopyright © 2014 American Pain Society. Published by Elsevier Inc. All rights reserved.pt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1528-8447pt_BR
dc.identifier.doi10.1016/j.jpain.2013.12.008pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/24412800pt_BR
dc.date.available2015-11-27T13:41:46Z-
dc.date.accessioned2015-11-27T13:41:46Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:41:46Z (GMT). No. of bitstreams: 1 pmed_24412800.pdf: 2053436 bytes, checksum: b65dccf3bd024e2df86d5b6be3b41e96 (MD5) Previous issue date: 2014en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201085-
dc.identifier.idPubmed24412800pt_BR
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