Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/201070
Type: Artigo de periódico
Title: Modulation Of Aldosterone Levels By -344 c/t Cyp11b2 Polymorphism And Spironolactone Use In Resistant Hypertension.
Author: Fontana, Vanessa
de Faria, Ana Paula Cabral
Barbaro, Natália Ruggeri
Sabbatini, Andréa Rodrigues
Modolo, Rodrigo
Lacchini, Riccardo
Moreno, Heitor
Abstract: Interindividual variability in plasma aldosterone levels comprises environmental and genetic sources. Increased aldosterone levels have been associated with higher risk of hypertension and target-organ damage related to hypertension. Aldosterone excess and intravascular volume expansion are implicated in pathophysiology of resistant hypertension (RH). We sought to investigate whether -344 C/T polymorphism (rs1799998) in aldosterone synthase gene (CYP11B2) is associated with plasma aldosterone levels in patients with resistant hypertension. Sixty-two patients with resistant hypertension were enrolled in this cross-sectional study. Genotypes were obtained by allelic discrimination assay using real time polymerase chain reaction. Multivariable linear regression was used to identify whether TT genotype was a predictor of aldosterone levels. No differences in clinical and laboratorial parameters were found among genotype groups. We found an additive effect of the T allele on plasma aldosterone concentration in RH. Also, there was higher aldosterone levels in TT homozygous under use of spironolactone compared with C carriers and compared with TT subjects who was not under use of spironolactone. TT genotype and the use of spironolactone were significant predictors of aldosterone levels in RH subjects. Plasma aldosterone concentration is significantly associated with -344 C/T CYP11B2 polymorphism and with the treatment with spironolactone in resistant hypertensive subjects.
Subject: Aged
Aldosterone
Alleles
Blood Pressure
Cytochrome P-450 Cyp11b2
Dna
Female
Genotype
Humans
Hypertension
Male
Middle Aged
Mineralocorticoid Receptor Antagonists
Polymorphism, Genetic
Spironolactone
Mineralocorticoid Receptor Antagonists
Aldosterone Synthase And Aldosterone Breakthrough
Refractory Hypertension
Rights: fechado
Identifier DOI: 10.1016/j.jash.2013.12.001
Address: http://www.ncbi.nlm.nih.gov/pubmed/24388430
Date Issue: 2014
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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